TXLNG taxilin gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: TXLNGprovided by HGNC
Official Full Name: taxilin gammaprovided by HGNC
Primary source: HGNC:HGNC:18578
See related: Ensembl:ENSG00000086712 MIM:300677; AllianceGenome:HGNC:18578
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ELRG; FIAT; LSR5; TXLNGX; CXorf15
Summary: This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression: Ubiquitous expression in adrenal (RPKM 8.1), fat (RPKM 7.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp22.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (16786466..16844519)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (16368976..16427050)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (16804589..16862642)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TXLNG improves insulin resistance in obese subjects in vitro and in vivo by inhibiting ATF4 transcriptional activity.
Title: TXLNG improves insulin resistance in obese subjects in vitro and in vivo by inhibiting ATF4 transcriptional activity.
alpha-/gamma-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
Title: α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
Taken together with the result that gamma-taxilin protein expression levels were decreased at the onset of mitosis, we propose that gamma-taxilin participates in Nek2A-mediated centrosome disjunction as a negative regulator through its interaction with Nek2A.
Title: γ-Taxilin temporally regulates centrosome disjunction in a Nek2A-dependent manner.
[review] First evidence of a functional interaction between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).
Title: Combinatorial control of ATF4-dependent gene transcription in osteoblasts.
evaluation of the effects of a novel environmental lipopolysaccharide-responding (Elrg) gene on the regulation of proliferation and cell cycle of the hepatoma-derived cell line, HepG2
Title: Over-expression and siRNA of a novel environmental lipopolysaccharide-responding gene on the cell cycle of the human hepatoma-derived cell line HepG2.
identification of isoforms of taxilin; interaction with syntaxin; tissue distribution [beta-taxilin, gamma-taxilin].
Title: Identification and characterization of taxilin isoforms.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484374

RH99226 (e-PCR)
- UniSTS:85116

DXS8320 (e-PCR)
- UniSTS:59292

DXS9836 (e-PCR)
- UniSTS:474052

Clone Names

FLJ11209, FLJ33481, MGC126621, MGC126625

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-taxilin

Names: environmental LPS-responding; environmental lipopolysaccharide-responding gene protein; factor inhibiting ATF4-mediated transcription; factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription; lipopolysaccharide specific response-5 protein; lipopolysaccharide-specific response protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016267.1 RefSeqGene

Range

5035..63088

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001168683.2 → NP_001162154.1 gamma-taxilin isoform 2

See identical proteins and their annotated locations for NP_001162154.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AA731379, AF143740, AK123142, AW197225, AY739713, DA516680, DB098819

Consensus CDS

CCDS55373.1

UniProtKB/Swiss-Prot

Q9NUQ3

Related

ENSP00000381222.4, ENST00000398155.4

Conserved Domains (2) summary

pfam09728
Location:35 → 313

Taxilin; Myosin-like coiled-coil protein

cl19219
Location:246 → 331

DUF342; Protein of unknown function (DUF342)
NM_018360.3 → NP_060830.2 gamma-taxilin isoform 1

See identical proteins and their annotated locations for NP_060830.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA731379, AF143740, AK123142, AW197225, BC101576, DA516680

Consensus CDS

CCDS14178.1

UniProtKB/Swiss-Prot

Q2KQ75, Q5JNZ7, Q9NUQ3, Q9P0X1

Related

ENSP00000369465.5, ENST00000380122.10

Conserved Domains (2) summary

pfam09728
Location:138 → 445

Taxilin; Myosin-like coiled-coil protein

cl19219
Location:378 → 463

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

16786466..16844519

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047442249.1 → XP_047298205.1 gamma-taxilin isoform X2
XM_024452400.2 → XP_024308168.1 gamma-taxilin isoform X1

Conserved Domains (1) summary

pfam09728
Location:98 → 405

Taxilin; Myosin-like coiled-coil protein
XM_017029631.2 → XP_016885120.1 gamma-taxilin isoform X3