GORASP2 golgi reassembly stacking protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GORASP2provided by HGNC
Official Full Name: golgi reassembly stacking protein 2provided by HGNC
Primary source: HGNC:HGNC:17500
See related: Ensembl:ENSG00000115806 MIM:608693; AllianceGenome:HGNC:17500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p59; GRS2; GOLPH6; GRASP55
Summary: This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression: Ubiquitous expression in thyroid (RPKM 25.6), placenta (RPKM 23.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q31.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (170928477..170967130)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (171405614..171444257)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (171784987..171823640)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.
Title: Golgi Reassembly Stacking Protein 2 Modulates Myometrial Contractility during Labor by Affecting ATP Production.
GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.
Title: GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.
GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.
Title: GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis.
An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
Title: An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
Title: Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
GRASP55: A Multifunctional Protein.
Title: GRASP55: A Multifunctional Protein.
Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.
Title: Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.
GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.
Title: GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion.
that SIRT2 regulates Golgi structure by modulating GRASP55 acetylation levels
Title: SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly.
here we identified a novel GORASP2-ALK rearrangement in a patient with ALK + LBCL with a unique ALK immunohistochemical staining pattern.
Title: Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of golgi reassembly stacking protein 2 (GORASP2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S1957E (e-PCR)
- UniSTS:153729

WI-16146 (e-PCR)
- UniSTS:8599

D2S2857 (e-PCR)
- UniSTS:33951

NIB308 (e-PCR)
- UniSTS:21920

G20588 (e-PCR)
- UniSTS:43183

A005Y03 (e-PCR)
- UniSTS:43184

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	NAS Non-traceable Author Statement more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in cis-Golgi network	NAS Non-traceable Author Statement more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Golgi reassembly-stacking protein 2

Names: golgi phosphoprotein 6; golgi reassembly stacking protein 2, 55kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201428.2 → NP_001188357.1 Golgi reassembly-stacking protein 2 isoform 2

See identical proteins and their annotated locations for NP_001188357.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC010092, AL117430, BQ004408

UniProtKB/TrEMBL

B4DNR1

Conserved Domains (1) summary

pfam04495
Location:1 → 137

GRASP55_65; GRASP55/65 PDZ-like domain
NM_015530.5 → NP_056345.3 Golgi reassembly-stacking protein 2 isoform 1

See identical proteins and their annotated locations for NP_056345.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC010092, BC007770, BQ004408

Consensus CDS

CCDS33325.1

UniProtKB/Swiss-Prot

B4DKT0, Q53TE3, Q96I74, Q96K84, Q9H8Y8, Q9H946, Q9UFW4

UniProtKB/TrEMBL

B4DNR1

Related

ENSP00000234160.4, ENST00000234160.5

Conserved Domains (3) summary

pfam04495
Location:69 → 205

GRASP55_65; GRASP55/65 PDZ-like domain

cl00117
Location:14 → 100

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

cl26464
Location:241 → 397

Atrophin-1; Atrophin-1 family