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    Rgs18 regulator of G-protein signaling 18 [ Mus musculus (house mouse) ]

    Gene ID: 64214, updated on 12-May-2024

    Summary

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    Official Symbol
    Rgs18provided by MGI
    Official Full Name
    regulator of G-protein signaling 18provided by MGI
    Primary source
    MGI:MGI:1927498
    See related
    Ensembl:ENSMUSG00000026357 AllianceGenome:MGI:1927498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables GTPase activator activity. Acts upstream of or within G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Located in cytoplasm. Is expressed in liver. Orthologous to human RGS18 (regulator of G protein signaling 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 3.7), liver E18 (RPKM 2.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rgs18 in Genome Data Viewer
    Location:
    1 F; 1 62.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (144628430..144651165, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (144752683..144775427, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02538 Neighboring gene STARR-positive B cell enhancer ABC_E5816 Neighboring gene predicted gene 7266 Neighboring gene STARR-seq mESC enhancer starr_02539 Neighboring gene regulator of G-protein signalling 21 Neighboring gene STARR-seq mESC enhancer starr_02540 Neighboring gene STARR-seq mESC enhancer starr_02541 Neighboring gene predicted gene, 22681 Neighboring gene cytokine receptor-like factor 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis. Alshbool FZ, et al. Biochem Biophys Res Commun, 2015 Jul 10. PMID 25969426
    2. Regulator of G-protein signaling 18 controls both platelet generation and function. Delesque-Touchard N, et al. PLoS One, 2014. PMID 25405900, Free PMC Article
    3. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival. DeHelian D, et al. Blood, 2020 Oct 8. PMID 32542378, Free PMC Article
    4. Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b. Sengupta A, et al. J Cell Sci, 2016 Jan 1. PMID 26567214, Free PMC Article
    5. Modulating platelet reactivity through control of RGS18 availability. Ma P, et al. Blood, 2015 Dec 10. PMID 26407691, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A regulatory node involving Galphaq, PLCbeta, and RGS proteins modulates platelet reactivity to critical agonists.
      Title: A regulatory node involving Gα(q), PLCβ, and RGS proteins modulates platelet reactivity to critical agonists.
    2. RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
      Title: RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
    3. these results identify Rgs18 as a new and crucial effector of Gfi1b that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.
      Title: Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b.
    4. Regulator of G-protein signaling 18 controls both platelet generation and function.
      Title: Regulator of G-protein signaling 18 controls both platelet generation and function.
    5. Regulated sequestration and release of RGS18 by intracellular binding proteins coordinates activating and inhibitory signaling networks in platelets. Substituting alanine for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1 complex.
      Title: Modulating platelet reactivity through control of RGS18 availability.
    6. RGS18 deficiency markedly shortened bleeding as well as occlusion times (in vivo). Furthermore, RGS18(-/-) platelets displayed hyper-responsiveness with regards to agonist induced aggregation
      Title: The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis.
    7. study is the first to show that RGS18 regulates megakaryopoiesis but also reveals its unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt signaling.
      Title: Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.
    8. RGS18 acts as a negative regulator of the acidosis-induced osteoclastogenic protein-coupled receptor 68/NFAT signaling pathway
      Title: RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117531

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of G-protein signaling 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412709.1 → NP_001399638.1  regulator of G-protein signaling 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102163

    2. NM_022881.6 → NP_075019.1  regulator of G-protein signaling 18 isoform 1

      See identical proteins and their annotated locations for NP_075019.1

      Status: VALIDATED

      Source sequence(s)
      AC102163
      Consensus CDS
      CCDS15350.1
      UniProtKB/Swiss-Prot
      Q99PG4
      UniProtKB/TrEMBL
      Q544K2
      Related
      ENSMUSP00000027603.4, ENSMUST00000027603.4
      Conserved Domains (1) summary
      cl02565
      Location:87 → 199
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      144628430..144651165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PG4.1 GenPept UniProtKB/Swiss-Prot:Q99PG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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