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    IMP3 IMP U3 small nucleolar ribonucleoprotein 3 [ Homo sapiens (human) ]

    Gene ID: 55272, updated on 2-May-2024

    Summary

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    Official Symbol
    IMP3provided by HGNC
    Official Full Name
    IMP U3 small nucleolar ribonucleoprotein 3provided by HGNC
    Primary source
    HGNC:HGNC:14497
    See related
    Ensembl:ENSG00000177971 MIM:612980; AllianceGenome:HGNC:14497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRMS2; MRPS4; C15orf12
    Summary
    This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: IMP3 (Gene ID: 55272) and IGF2BP3 (Gene ID: 10643) share the IMP3 symbol/alias in common. IMP3 is a widely used alternative name for insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), which can be confused with the official symbol for IMP3, U3 small nucleolar ribonucleoprotein (IMP3). [17 May 2018]
    Orthologs
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    Genomic context

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    See IMP3 in Genome Data Viewer
    Location:
    15q24.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75639093..75640224, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73509801..73510932, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75931434..75932565, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 9 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6673 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75871223-75871821 Neighboring gene snurportin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75940037-75940728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75943426-75944362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945327-75945879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945880-75946431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949231-75949732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949733-75950232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75952205-75952778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75953927-75954500 Neighboring gene sorting nexin 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75966659-75967446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75974798-75975642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75978522-75979027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75979028-75979532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75985202-75985952 Neighboring gene Sharpr-MPRA regulatory region 4583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75989701-75990450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75990451-75991198 Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75993083-75993582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75993590-75994515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Correlations of expressions of IMP3 and VEGF with stage of osteosarcoma, microvascular density and pulmonary metastasis. Kong X, et al. J BUON, 2020 Sep-Oct. PMID 33277867
    2. The expression of ribonuclear protein IMP3 in laryngeal carcinogenesis. Maržić D, et al. Pathol Res Pract, 2020 Jun. PMID 32370989
    3. Bile duct adenoma and small-sized small duct type intrahepatic cholangiocarcinoma show distinct differences in genetic alterations, expression of IMP3 and EZH2 and stromal and inflammatory components. Sasaki M, et al. Histopathology, 2023 Aug. PMID 37140546
    4. RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA. Zhang M, et al. J Exp Clin Cancer Res, 2021 Jun 21. PMID 34154626, Free PMC Article
    5. IMP3 protein is an independent prognostic factor of clinical stage II rectal cancer. Bevanda Glibo D, et al. Sci Rep, 2021 May 25. PMID 34035433, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA.
      Title: RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA.
    2. Correlations of expressions of IMP3 and VEGF with stage of osteosarcoma, microvascular density and pulmonary metastasis.
      Title: Correlations of expressions of IMP3 and VEGF with stage of osteosarcoma, microvascular density and pulmonary metastasis.
    3. The expression of ribonuclear protein IMP3 in laryngeal carcinogenesis.
      Title: The expression of ribonuclear protein IMP3 in laryngeal carcinogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10968, DKFZp586L0118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mpp10 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Mpp10 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    part_of preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U3 small nucleolar ribonucleoprotein protein IMP3
    Names
    IMP3, U3 small nucleolar ribonucleoprotein, homolog
    U3 snoRNP protein 3 homolog
    U3 snoRNP protein IMP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018285.4 → NP_060755.1  U3 small nucleolar ribonucleoprotein protein IMP3

      See identical proteins and their annotated locations for NP_060755.1

      Status: REVIEWED

      Source sequence(s)
      AC105020
      Consensus CDS
      CCDS10282.1
      UniProtKB/Swiss-Prot
      B3KQ67, Q53G10, Q9NV31
      Related
      ENSP00000385217.1, ENST00000403490.3
      Conserved Domains (1) summary
      COG0522
      Location:1 → 168
      RpsD; Ribosomal protein S4 or related protein [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      75639093..75640224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      73509801..73510932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NV31.1 GenPept UniProtKB/Swiss-Prot:Q9NV31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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