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    SYTL4 synaptotagmin like 4 [ Homo sapiens (human) ]

    Gene ID: 94121, updated on 3-Apr-2024

    Summary

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    Official Symbol
    SYTL4provided by HGNC
    Official Full Name
    synaptotagmin like 4provided by HGNC
    Primary source
    HGNC:HGNC:15588
    See related
    Ensembl:ENSG00000102362 MIM:300723; AllianceGenome:HGNC:15588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLP4
    Summary
    This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
    Expression
    Broad expression in ovary (RPKM 19.6), endometrium (RPKM 12.8) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xq22.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (100674491..100732121, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99116950..99174573, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (99929488..99987108, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20914 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:99890767-99891382 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:99891383-99891998 Neighboring gene tetraspanin 6 Neighboring gene Sharpr-MPRA regulatory region 6756 Neighboring gene Sharpr-MPRA regulatory region 14263 Neighboring gene sushi repeat containing protein X-linked 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20916 Neighboring gene Sharpr-MPRA regulatory region 15282 Neighboring gene peptidylprolyl isomerase A pseudogene 89 Neighboring gene RAD21 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin. Alnaas AA, et al. J Biol Chem, 2021 Jan-Jun. PMID 33277360, Free PMC Article
    2. The unique N-terminal zinc finger of synaptotagmin-like protein 4 reveals FYVE structure. Miyamoto K, et al. Protein Sci, 2017 Dec. PMID 28906046, Free PMC Article
    3. Granuphilin exclusively mediates functional granule docking to the plasma membrane. Mizuno K, et al. Sci Rep, 2016 Apr 1. PMID 27032672, Free PMC Article
    4. Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2. Wan C, et al. Chem Phys Lipids, 2015 Feb. PMID 25595293
    5. The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids. Lyakhova TA, et al. Chem Phys Lipids, 2014 Sep. PMID 24184645, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.
      Title: Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.
    2. SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.
      Title: SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.
    3. LMP1 upregulates SDC2 and SYTL4.
      Title: Epstein-Barr virus-encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan-2 and synaptotagmin-like-4 in nasopharyngeal carcinoma cells.
    4. Determined the solution structure of human synaptotagmin-like protein 4 (Slp4). Through modification of cysteine residues, found Slp4 binding of two zinc atoms is required for correct folding.
      Title: The unique N-terminal zinc finger of synaptotagmin-like protein 4 reveals FYVE structure.
    5. Granuphilin makes granules immobile and fusion-reluctant beneath the plasma membrane. Those granuphilin-positive, docked granules release a portion of granuphilin upon fusion, and fuse at a frequency and time course similar to those of granuphilin-negative undocked granules. Granuphilin forms a 180-nm cluster at the site of each docked granule, along with granuphilin-interacting Rab27a and Munc18-1 clusters.
      Title: Granuphilin exclusively mediates functional granule docking to the plasma membrane.
    6. GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3.
      Title: Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
    7. Phosphatidylinositol 4,5-bisphosphate binds to the concave surface of granuphilin-C2A domain. The key residues involved in the binding were validated by mutation analysis.
      Title: Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2.
    8. the mechanisms of granuphilin plasma membrane targeting and release
      Title: The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids.
    9. Recruitment of STXBP1 by the Rab27A effector SYTL4 promotes Weibel-Palade body exocytosis.
      Title: STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a.
    10. Slp4 and Rab8 are expressed and interact in human platelets, and might be involved in dense granule release.
      Title: Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40960, DKFZp451P0116

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in platelet alpha granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 4
    Names
    exophilin-2
    granuphilin-a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016858.2 RefSeqGene

      Range
      5026..62656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129896.3 → NP_001123368.1  synaptotagmin-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001123368.1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    2. NM_001174068.2 → NP_001167539.1  synaptotagmin-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001167539.1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000276141.6, ENST00000276141.10
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    3. NM_001370160.1 → NP_001357089.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    4. NM_001370161.1 → NP_001357090.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000263033.5, ENST00000263033.9
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    5. NM_001370162.1 → NP_001357091.1  synaptotagmin-like protein 4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL390040
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8 → 121
      FYVE_2; FYVE-type zinc finger

    6. NM_001370163.1 → NP_001357092.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    7. NM_001370164.1 → NP_001357093.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    8. NM_001370165.1 → NP_001357094.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000362080.1, ENST00000372989.6
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    9. NM_001370166.1 → NP_001357095.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    10. NM_001370167.1 → NP_001357096.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Related
      ENSP00000509693.1, ENST00000685623.1
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    11. NM_001370168.1 → NP_001357097.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    12. NM_001370169.1 → NP_001357098.1  synaptotagmin-like protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    13. NM_080737.3 → NP_542775.2  synaptotagmin-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_542775.2

      Status: REVIEWED

      Source sequence(s)
      AL390040
      Consensus CDS
      CCDS14472.1
      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1
      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 661
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:8 → 121
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      100674491..100732121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029968.2 → XP_016885457.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8 → 121
      FYVE_2; FYVE-type zinc finger

    2. XM_017029967.3 → XP_016885456.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8 → 121
      FYVE_2; FYVE-type zinc finger

    3. XM_047442649.1 → XP_047298605.1  synaptotagmin-like protein 4 isoform X1

    4. XM_017029966.2 → XP_016885455.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A8K973, B2R7R4
      Conserved Domains (4) summary
      cd04020
      Location:496 → 622
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:357 → 481
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:58 → 107
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      pfam02318
      Location:8 → 121
      FYVE_2; FYVE-type zinc finger

    5. XM_047442651.1 → XP_047298607.1  synaptotagmin-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5H9J3, Q5JPG8, Q8N9P4, Q96C24, Q9H4R0, Q9H4R1

    6. XM_047442650.1 → XP_047298606.1  synaptotagmin-like protein 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      99116950..99174573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328140.1 → XP_054184115.1  synaptotagmin-like protein 4 isoform X1

    2. XM_054328137.1 → XP_054184112.1  synaptotagmin-like protein 4 isoform X1

    3. XM_054328139.1 → XP_054184114.1  synaptotagmin-like protein 4 isoform X1

    4. XM_054328138.1 → XP_054184113.1  synaptotagmin-like protein 4 isoform X1

    5. XM_054328142.1 → XP_054184117.1  synaptotagmin-like protein 4 isoform X2

    6. XM_054328141.1 → XP_054184116.1  synaptotagmin-like protein 4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96C24.2 GenPept UniProtKB/Swiss-Prot:Q96C24

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