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    Akr1d1 aldo-keto reductase family 1, member D1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192242, updated on 2-May-2024

    Summary

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    Official Symbol
    Akr1d1provided by RGD
    Official Full Name
    aldo-keto reductase family 1, member D1provided by RGD
    Primary source
    RGD:620752
    See related
    Ensembl:ENSRNOG00000013004 AllianceGenome:RGD:620752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 3-oxo-5-beta-steroid 4-dehydrogenase activity. Predicted to be involved in cellular hormone metabolic process; cholesterol catabolic process; and digestion. Predicted to act upstream of or within bile acid biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 2. Orthologous to human AKR1D1 (aldo-keto reductase family 1 member D1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 2347.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akr1d1 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (67121288..67154543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (66154246..66187505)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (65110706..65143930)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, iota Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene uncharacterized LOC134486755 Neighboring gene high-mobility group box 1, pseudogene 18 Neighboring gene tripartite motif-containing 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as delta 4-3-ketosteroid 5 beta-reductase. Zhu Y, et al. Hepatology, 1996 Jan. PMID 8550030
    2. delta 4-3-Oxosteroid 5 beta-reductase. Structure and function. Onishi Y, et al. Biol Chem Hoppe Seyler, 1991 Dec. PMID 1789929
    3. Molecular cloning and sequence analysis of cDNA encoding delta 4-3-ketosteroid 5 beta-reductase of rat liver. Onishi Y, et al. FEBS Lett, 1991 Jun 3. PMID 1710579
    4. Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme. Kondo KH, et al. Eur J Biochem, 1994 Jan 15. PMID 7508385
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-oxo-5-beta-steroid 4-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Delta4-3-oxosteroid 5beta-reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in C21-steroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in androgen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in digestion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member D1
    Names
    3-oxo-5-beta-steroid 4-dehydrogenase
    aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
    delta(4)-3-ketosteroid 5-beta-reductase
    delta(4)-3-oxosteroid 5-beta-reductase
    NP_620239.2
    XP_006236347.1
    XP_038962921.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138884.2 → NP_620239.2  aldo-keto reductase family 1 member D1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P31210
      UniProtKB/TrEMBL
      A0A8I5ZSN6, A6IEQ7
      Related
      ENSRNOP00000080261.1, ENSRNOT00000103598.1
      Conserved Domains (1) summary
      cd19109
      Location:15 → 321
      AKR_AKR1D1-3; AKR1D family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      67121288..67154543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106993.2 → XP_038962921.1  aldo-keto reductase family 1 member D1 isoform X2

      UniProtKB/Swiss-Prot
      P31210
      Conserved Domains (1) summary
      cl00470
      Location:15 → 295
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    2. XM_006236285.3 → XP_006236347.1  aldo-keto reductase family 1 member D1 isoform X1

      UniProtKB/Swiss-Prot
      P31210
      UniProtKB/TrEMBL
      A0A0G2KAV5
      Related
      ENSRNOP00000075542.1
      Conserved Domains (2) summary
      COG0656
      Location:28 → 297
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:26 → 289
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31210.1 GenPept UniProtKB/Swiss-Prot:P31210

    Gene LinkOut

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