Zc3hav1 zinc finger CCCH-type containing, antiviral 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zc3hav1provided by RGD
Official Full Name: zinc finger CCCH-type containing, antiviral 1provided by RGD
Primary source: RGD:628694
See related: Ensembl:ENSRNOG00000013948 AllianceGenome:RGD:628694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zap; ARTD13; PARP13
Summary: Enables RNA binding activity and identical protein binding activity. Involved in several processes, including cellular response to virus; negative regulation of viral genome replication; and regulation of defense response to virus by host. Located in cytoplasm and nucleus. Orthologous to human ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 294.7), Spleen (RPKM 284.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q23

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (67979055..68029353, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (67012129..67062428, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (66012111..66062160, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that phosphorylation of ZAP by GSK3beta modulates ZAP activity.
Title: Glycogen synthase kinase 3β (GSK3β) modulates antiviral activity of zinc-finger antiviral protein (ZAP).
Zap molecules interact to form a dimer that binds to a Zap-responsive RNA molecule containing two Zap-binding modules.
Title: Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA.
The integrity of the very N-terminal domain and the first and second zinc-finger motifs appear to be required for ZAP's antiviral activity.
Title: Mutagenesis analysis of the zinc-finger antiviral protein.
expression inhibits the replication of multiple members of the Alphavirus genus within the Togaviridae, including Sindbis virus, Semliki Forest virus, Ross River virus, and Venezuelan equine encephalitis virus
Title: Expression of the zinc-finger antiviral protein inhibits alphavirus replication.
Results demonstrate that ZAP is predominantly localized in the cytoplasm at steady state but shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner.
Title: ZAP is a CRM1-dependent nucleocytoplasmic shuttling protein.
Expression of the gene caused a profound and specific loss of viral messenger RNAs from the cytoplasm without affecting the levels of nuclear mRNAs; findings suggests the existence of a previously unknown machinery for the inhibition of virus replication
Title: Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132456 (e-PCR)
- UniSTS:215739

BQ205634 (e-PCR)
- UniSTS:261353

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
NOT enables NAD+ ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables NAD+ binding	ISO Inferred from Sequence Orthology more info
NOT enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger CCCH-type antiviral protein 1

Names: ADP-ribosyltransferase diphtheria toxin-like 13; CCCH-type zinc finger antiviral protein (Zap); inactive Poly [ADP-ribose] polymerase 13; rZAP; zinc finger CCCH type, antiviral 1; zinc finger antiviral protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398725.1 → NP_001385654.1 zinc finger CCCH-type antiviral protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

F7F0B1

Related

ENSRNOP00000018782.3, ENSRNOT00000018782.6

Conserved Domains (4) summary

cd01439
Location:860 → 969

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam02825
Location:686 → 756

WWE; WWE domain

pfam18606
Location:5 → 66

HTH_53; Zap helix turn helix N-terminal domain

pfam18633
Location:143 → 170

zf-CCCH_8; Zinc-finger antiviral protein (ZAP) zinc finger domain 3
NM_173045.3 → NP_766633.2 zinc finger CCCH-type antiviral protein 1 isoform 2

See identical proteins and their annotated locations for NP_766633.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q8K3Y6

UniProtKB/TrEMBL

A2RRT6

Conserved Domains (1) summary

pfam02825
Location:683 → 759

WWE; WWE domain