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    Trim24 tripartite motif-containing 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500084, updated on 13-Apr-2024

    Summary

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    Symbol
    Trim24provided by RGD
    Full Name
    tripartite motif-containing 24provided by RGD
    Primary source
    RGD:1560596
    See related
    Ensembl:ENSRNOG00000013251 AllianceGenome:RGD:1560596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including estrogen response element binding activity; lysine-acetylated histone binding activity; and p53 binding activity. Involved in response to peptide hormone. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Orthologous to human TRIM24 (tripartite motif containing 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 118.2), Testes (RPKM 75.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim24 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (67534240..67659014)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (66567342..66692029)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (65632278..65684746)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member D1 Neighboring gene uncharacterized LOC134486755 Neighboring gene high-mobility group box 1, pseudogene 18 Neighboring gene SVOP like Neighboring gene ATPase H+ transporting V0 subunit a4 Neighboring gene transmembrane protein 213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Ignat M, et al. Proc Natl Acad Sci U S A, 2008 Feb 19. PMID 18287084, Free PMC Article
    2. Expression of the transcriptional intermediary factor TIF1alpha during mouse development and in the reproductive organs. Niederreither K, et al. Mech Dev, 1999 Oct. PMID 10525195
    3. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. Klugbauer S, et al. Oncogene, 1999 Jul 29. PMID 10439047
    4. Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Khetchoumian K, et al. Nat Genet, 2007 Dec. PMID 18026104
    5. Trim24 targets endogenous p53 for degradation. Allton K, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19556538, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estrogen response element binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of vitamin D receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perichromatin fibrils ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription intermediary factor 1-alpha
    Names
    Ab2-427
    NP_001382682.1
    XP_063142572.1
    XP_063142573.1
    XP_063142574.1
    XP_063142575.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395753.1 → NP_001382682.1  transcription intermediary factor 1-alpha

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AI80, A6IEQ8
      Related
      ENSRNOP00000094653.1, ENSRNOT00000113281.1
      Conserved Domains (8) summary
      cd05502
      Location:900 → 1007
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:266 → 392
      BBC; B-Box C-terminal domain
      smart00818
      Location:490 → 563
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd15624
      Location:828 → 873
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
      cd00162
      Location:52 → 130
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19828
      Location:218 → 274
      Bbox2_TIF1a_C-VI; B-box-type 2 zinc finger found in transcription intermediary factor 1-alpha (TIF1-alpha)
      cd19845
      Location:161 → 205
      Bbox1_TIF1a_C-VI; B-box-type 1 zinc finger found in transcription intermediary factor 1-alpha (TIF1-alpha)
      cl17238
      Location:49 → 134
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      67534240..67659014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286502.1 → XP_063142572.1  transcription intermediary factor 1-alpha isoform X1

      UniProtKB/TrEMBL
      A6IEQ9

    2. XM_063286504.1 → XP_063142574.1  transcription intermediary factor 1-alpha isoform X2

    3. XM_063286503.1 → XP_063142573.1  transcription intermediary factor 1-alpha isoform X2

    4. XM_063286505.1 → XP_063142575.1  transcription intermediary factor 1-alpha isoform X2

    RNA

    1. XR_010065691.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001044266.1: Suppressed sequence

      Description
      NM_001044266.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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