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    PSG3 pregnancy specific beta-1-glycoprotein 3 [ Homo sapiens (human) ]

    Gene ID: 5671, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PSG3provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 3provided by HGNC
    Primary source
    HGNC:HGNC:9520
    See related
    Ensembl:ENSG00000221826 MIM:176392; AllianceGenome:HGNC:9520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 164.7) See more
    Orthologs
    all
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    Genomic context

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    See PSG3 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42721642..42740481, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45540609..45559440, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43225794..43244633, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule pseudogene 5 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:43179943-43180536 Neighboring gene ribosomal protein S10 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:43245994-43246209 Neighboring gene pregnancy specific beta-1-glycoprotein 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43278258-43278758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43278759-43279259 Neighboring gene CEA cell adhesion molecule pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Pregnancy specific beta 1-glycoprotein in human intestine. Shupert WL, et al. Mol Cell Biochem, 1993 Mar 24. PMID 8487756
    2. Expression of CEA-related genes in the first trimester human placenta. McLenachan T, et al. Biochem Biophys Res Commun, 1989 Aug 15. PMID 2788412
    3. Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1-glycoprotein gene family. Streydio C, et al. Genomics, 1990 Aug. PMID 2387594
    4. Molecular cloning of a cDNA for human pregnancy-specific beta 1-glycoprotein:homology with human carcinoembryonic antigen and related proteins. Rooney BC, et al. Gene, 1988 Nov 30. PMID 3265688
    5. Expression of the pregnancy-specific beta 1-glycoprotein genes in human testis. Borjigin J, et al. Biochem Biophys Res Commun, 1990 Jan 30. PMID 2302228

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific beta-1-glycoprotein 3
    Names
    PS-beta-G-3
    PSBG-3
    carcinoembryonic antigen SG5
    pregnancy-specific glycoprotein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021016.4 → NP_066296.2  pregnancy-specific beta-1-glycoprotein 3 precursor

      See identical proteins and their annotated locations for NP_066296.2

      Status: VALIDATED

      Source sequence(s)
      BG620196, DA833589, M93061
      Consensus CDS
      CCDS12611.1
      UniProtKB/Swiss-Prot
      Q08265, Q16557, Q9BRW2, Q9UPL4, Q9UQ77
      UniProtKB/TrEMBL
      Q96QL5
      Related
      ENSP00000332215.5, ENST00000327495.10
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339 → 413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335 → 413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42721642..42740481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527127.3 → XP_011525429.1  pregnancy-specific beta-1-glycoprotein 3 isoform X2

      Conserved Domains (3) summary
      cd05774
      Location:58 → 160
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:100 → 143
      IG_like; Immunoglobulin like
      cl11960
      Location:170 → 258
      Ig; Immunoglobulin domain

    2. XM_011527126.3 → XP_011525428.1  pregnancy-specific beta-1-glycoprotein 3 isoform X1

      UniProtKB/TrEMBL
      Q9UPK9
      Conserved Domains (4) summary
      cd05774
      Location:58 → 160
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:268 → 342
      IG_like; Immunoglobulin like
      pfam13895
      Location:264 → 342
      Ig_2; Immunoglobulin domain
      cl11960
      Location:170 → 258
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45540609..45559440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321488.1 → XP_054177463.1  pregnancy-specific beta-1-glycoprotein 3 isoform X2

    2. XM_054321487.1 → XP_054177462.1  pregnancy-specific beta-1-glycoprotein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16557.2 GenPept UniProtKB/Swiss-Prot:Q16557

    Gene LinkOut

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