ITGAD integrin subunit alpha D [Homo sapiens (human)] - Gene

Summary

Official Symbol: ITGADprovided by HGNC
Official Full Name: integrin subunit alpha Dprovided by HGNC
Primary source: HGNC:HGNC:6146
See related: Ensembl:ENSG00000156886 MIM:602453; AllianceGenome:HGNC:6146
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADB2; CD11D
Summary: This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression: Biased expression in spleen (RPKM 11.2), lymph node (RPKM 2.1) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p11.2

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (31393335..31426505)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (31780736..31813905)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (31404656..31437826)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC02190 inhibits the embryo-endometrial attachment by decreasing ITGAD expression.
Title: LINC02190 inhibits the embryo-endometrial attachment by decreasing ITGAD expression.
findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development.
Title: The Upregulation of Integrin α(D)β(2) (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.
These results expand the potential for CD11d to regulate lymphocyte migration and tissue retention, and illuminate the possibility of a previously unconsidered role for CD11d in leukocyte biology and disease.
Title: CD11d β2 integrin expression on human NK, B, and γδ T cells.
alpha(D)beta(2) is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans
Title: Integrin αDβ2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling.
The effects of anti-CD11d treatment improves functional recovery in a rat model of repeated concussion.
Title: Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion.
the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively.
Title: On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3.
CD11d expression increased in the subcutaneous white adipose tissue of obese adult women; this appears to be a common feature of obesity.
Title: Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women.
multiple CD11d domains play a role in controlling intracellular location and association with CD18.
Title: The extracellular domain of CD11d regulates its cell surface expression.
a longer isoform of gut-enriched Kruppel-like factor 4 (GKLF) we term GKLFa interacts with the CD11d promoter
Title: The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-110391 (e-PCR)
- UniSTS:167830

D17S610 (e-PCR)
- UniSTS:46230

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IC Inferred by Curator more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: integrin alpha-D

Names: CD11 antigen-like family member D; beta-2 integrin alphaD subunit; leukointegrin alpha D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050624.2 RefSeqGene

Range

5002..38172

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001318185.2 → NP_001305114.1 integrin alpha-D isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC026471, AC093520

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:453 → 495

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1125 → 1139

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:617 → 958

Integrin_alpha2; Integrin alpha
NM_005353.3 → NP_005344.2 integrin alpha-D isoform 2 precursor

See identical proteins and their annotated locations for NP_005344.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.

Source sequence(s)

AC026471, AC093520

Consensus CDS

CCDS32438.1

UniProtKB/Swiss-Prot

Q13349, Q15575, Q15576

UniProtKB/TrEMBL

Q59H14

Related

ENSP00000373854.2, ENST00000389202.3

Conserved Domains (4) summary

smart00191
Location:453 → 509

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1124 → 1138

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:616 → 957

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

31393335..31426505

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011545835.4 → XP_011544137.1 integrin alpha-D isoform X1

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1153 → 1167

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:628 → 933

Integrin_alpha2; Integrin alpha
XM_017023215.3 → XP_016878704.1 integrin alpha-D isoform X6

UniProtKB/TrEMBL

Q59H14
XM_011545839.3 → XP_011544141.1 integrin alpha-D isoform X5

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1136 → 1150

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:628 → 969

Integrin_alpha2; Integrin alpha
XM_011545837.3 → XP_011544139.1 integrin alpha-D isoform X3

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1152 → 1166

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:628 → 932

Integrin_alpha2; Integrin alpha
XM_011545844.4 → XP_011544146.1 integrin alpha-D isoform X11

UniProtKB/TrEMBL

Q59H14

Conserved Domains (3) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:961 → 975

Integrin_alpha; Integrin alpha cytoplasmic region
XM_011545836.4 → XP_011544138.1 integrin alpha-D isoform X2

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:464 → 520

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1152 → 1166

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:627 → 932

Integrin_alpha2; Integrin alpha
XM_011545838.3 → XP_011544140.1 integrin alpha-D isoform X4

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:453 → 495

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1142 → 1156

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:617 → 922

Integrin_alpha2; Integrin alpha
XM_047434071.1 → XP_047290027.1 integrin alpha-D isoform X8
XM_011545841.3 → XP_011544143.1 integrin alpha-D isoform X7

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:453 → 509

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1123 → 1137

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:616 → 956

Integrin_alpha2; Integrin alpha
XM_011545842.4 → XP_011544144.1 integrin alpha-D isoform X9

UniProtKB/TrEMBL

Q59H14

Conserved Domains (4) summary

smart00191
Location:377 → 419

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1066 → 1080

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:541 → 846

Integrin_alpha2; Integrin alpha
XM_011545847.4 → XP_011544149.1 integrin alpha-D isoform X14

Conserved Domains (2) summary

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:741 → 755

Integrin_alpha; Integrin alpha cytoplasmic region
XM_011545843.4 → XP_011544145.1 integrin alpha-D isoform X10

UniProtKB/TrEMBL

Q59H14

Conserved Domains (3) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:628 → 933

Integrin_alpha2; Integrin alpha
XM_011545845.4 → XP_011544147.1 integrin alpha-D isoform X12

Conserved Domains (2) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
XM_011545848.4 → XP_011544150.1 integrin alpha-D isoform X15

Conserved Domains (2) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
XM_011545846.4 → XP_011544148.1 integrin alpha-D isoform X13

Conserved Domains (2) summary

smart00191
Location:464 → 506

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...