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    SGK2 serum/glucocorticoid regulated kinase 2 [ Homo sapiens (human) ]

    Gene ID: 10110, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SGK2provided by HGNC
    Official Full Name
    serum/glucocorticoid regulated kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:13900
    See related
    Ensembl:ENSG00000101049 MIM:607589; AllianceGenome:HGNC:13900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H-SGK2; dJ138B7.2
    Summary
    This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
    Expression
    Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SGK2 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (43559027..43585627)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45292229..45318829)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42187667..42214267)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1251, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12927 Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene transmembrane protein 14C-like Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42173308-42173524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42236005-42236846 Neighboring gene intraflagellar transport 52 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42266543-42266756 Neighboring gene ribosomal protein L27a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells. Ranzuglia V, et al. Oncogene, 2020 Oct. PMID 32848212, Free PMC Article
    2. SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells. Liu Y, et al. Eur J Surg Oncol, 2020 Oct. PMID 32565024
    3. SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation. Liu Y, et al. Eur Rev Med Pharmacol Sci, 2019 Apr. PMID 31002126
    4. Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis. Gotoh S, et al. Sci Rep, 2015 Sep 22. PMID 26392083, Free PMC Article
    5. Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies. Náray-Fejes-Tóth A, et al. Mol Cell Endocrinol, 2004 Mar 31. PMID 15134818

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
      Title: SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
    2. SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells.
      Title: SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells.
    3. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.
      Title: Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.
    4. SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.
      Title: SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.
    5. Loss of the paternally derived allele of the imprinted SGK2 gene is associated with Shwachman-Diamond syndrome.
      Title: Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.
    6. These findings suggest that SGK2 promotes hepatocellular carcinoma progression and mediates glycogen synthase kinase 3 beta/beta-catenin signaling in hepatocellular carcinoma cells.
      Title: SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.
    7. SGK2 stimulated hOAT4 transport activity by abrogating the inhibitory effect of Nedd4-2 on the transporter.
      Title: Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.
    8. Activation of hepatocyte pregnane X receptor is mediated through serum- and glucocorticoid-regulated kinase (SGK)2.
      Title: Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.
    9. Glucocorticoid inducible kinase isoforms SGK1-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo.
      Title: The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.
    10. All three members of the SGK family of kinases SGK1-3 and protein kinase B stimulate the slowly activating K(+) channel KCNE1/KCNQ1. The kinases may thus participate in the regulation of KCNE1-dependent transport and excitability.
      Title: Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables sodium channel regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Sgk2
    Names
    SGK2, serine/threonine kinase 2
    NP_001186193.1
    NP_057360.3
    NP_733794.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029448.2 RefSeqGene

      Range
      5033..31633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1050

    mRNA and Protein(s)

    1. NM_001199264.2 → NP_001186193.1  serine/threonine-protein kinase Sgk2

      See identical proteins and their annotated locations for NP_001186193.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      BC065511, DA244897
      Consensus CDS
      CCDS13321.1
      UniProtKB/Swiss-Prot
      Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
      UniProtKB/TrEMBL
      A8K0N1
      Related
      ENSP00000392795.3, ENST00000423407.7
      Conserved Domains (1) summary
      cd05603
      Location:39 → 359
      STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

    2. NM_016276.5 → NP_057360.3  serine/threonine-protein kinase Sgk2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest transcript. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      AF186470, BC065511, CD627734, Z98752
      Consensus CDS
      CCDS13321.1
      UniProtKB/Swiss-Prot
      Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
      UniProtKB/TrEMBL
      A8K0N1
      Related
      ENSP00000340608.5, ENST00000341458.10
      Conserved Domains (1) summary
      cd05603
      Location:39 → 359
      STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

    3. NM_170693.3 → NP_733794.1  serine/threonine-protein kinase Sgk2

      See identical proteins and their annotated locations for NP_733794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      AF169034, BC065511, DB183229
      Consensus CDS
      CCDS13321.1
      UniProtKB/Swiss-Prot
      Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
      UniProtKB/TrEMBL
      A8K0N1
      Related
      ENSP00000362192.1, ENST00000373100.7
      Conserved Domains (1) summary
      cd05603
      Location:39 → 359
      STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      43559027..43585627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      45292229..45318829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBY8.2 GenPept UniProtKB/Swiss-Prot:Q9HBY8

    Gene LinkOut

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