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    ZSWIM1 zinc finger SWIM-type containing 1 [ Homo sapiens (human) ]

    Gene ID: 90204, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZSWIM1provided by HGNC
    Official Full Name
    zinc finger SWIM-type containing 1provided by HGNC
    Primary source
    HGNC:HGNC:16155
    See related
    Ensembl:ENSG00000168612 AllianceGenome:HGNC:16155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf162
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 3.0), testis (RPKM 2.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZSWIM1 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45880920..45885266)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47617414..47621760)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44509866..44513905)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene sorting nexin family member 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44470503-44471055 Neighboring gene acyl-CoA thioesterase 8 Neighboring gene MPRA-validated peak4224 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44482305-44482834 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44482835-44483364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44483365-44483894 Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44514972-44515472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44515473-44515973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44519312-44520021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17954 Neighboring gene spermatogenesis associated 25 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZSWIM1: a novel biomarker in T helper cell differentiation. Ko KK, et al. Immunol Lett, 2014 Aug. PMID 24508175
    2. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
    3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    5. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis.
      Title: ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis.
    2. The activation sensitive nature of ZSWIM1 expression suggests that it may play a novel role in the development or function of T helper cells.
      Title: ZSWIM1: a novel biomarker in T helper cell differentiation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger SWIM domain-containing protein 1
    Names
    zinc finger, SWIM domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080603.5 → NP_542170.3  zinc finger SWIM domain-containing protein 1

      See identical proteins and their annotated locations for NP_542170.3

      Status: VALIDATED

      Source sequence(s)
      AL008726
      Consensus CDS
      CCDS13382.2
      UniProtKB/Swiss-Prot
      Q5JZH2, Q9BR11, Q9BR12, Q9BV30
      UniProtKB/TrEMBL
      A8K5I9
      Related
      ENSP00000361601.1, ENST00000372523.1
      Conserved Domains (1) summary
      pfam04434
      Location:379 → 404
      SWIM; SWIM zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      45880920..45885266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260611.5 → XP_005260668.1  zinc finger SWIM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005260668.1

      UniProtKB/Swiss-Prot
      Q5JZH2, Q9BR11, Q9BR12, Q9BV30
      UniProtKB/TrEMBL
      A8K5I9
      Conserved Domains (1) summary
      pfam04434
      Location:379 → 404
      SWIM; SWIM zinc finger

    2. XM_005260610.6 → XP_005260667.1  zinc finger SWIM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005260667.1

      UniProtKB/Swiss-Prot
      Q5JZH2, Q9BR11, Q9BR12, Q9BV30
      UniProtKB/TrEMBL
      A8K5I9
      Conserved Domains (1) summary
      pfam04434
      Location:379 → 404
      SWIM; SWIM zinc finger

    3. XM_011529100.3 → XP_011527402.1  zinc finger SWIM domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011527402.1

      UniProtKB/Swiss-Prot
      Q5JZH2, Q9BR11, Q9BR12, Q9BV30
      UniProtKB/TrEMBL
      A8K5I9
      Conserved Domains (1) summary
      pfam04434
      Location:379 → 404
      SWIM; SWIM zinc finger

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      47617414..47621760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324203.1 → XP_054180178.1  zinc finger SWIM domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5JZH2, Q9BR11, Q9BR12, Q9BV30

    2. XM_054324204.1 → XP_054180179.1  zinc finger SWIM domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5JZH2, Q9BR11, Q9BR12, Q9BV30

    3. XM_054324205.1 → XP_054180180.1  zinc finger SWIM domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5JZH2, Q9BR11, Q9BR12, Q9BV30
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BR11.2 GenPept UniProtKB/Swiss-Prot:Q9BR11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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