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    Stx11 syntaxin 11 [ Mus musculus (house mouse) ]

    Gene ID: 74732, updated on 14-May-2024

    Summary

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    Official Symbol
    Stx11provided by MGI
    Official Full Name
    syntaxin 11provided by MGI
    Primary source
    MGI:MGI:1921982
    See related
    Ensembl:ENSMUSG00000039232 AllianceGenome:MGI:1921982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830405C08Rik
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within cellular response to interferon-gamma and leukocyte degranulation. Located in phagocytic vesicle. Is expressed in femur; fibula; humerus; scapula; and tibia. Used to study familial hemophagocytic lymphohistiocytosis 4. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 4. Orthologous to human STX11 (syntaxin 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 7.1), lung adult (RPKM 6.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A2; 10 4.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (12813961..12840242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (12938217..12964498, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene utrophin Neighboring gene cofilin-1 pseudogene Neighboring gene RIKEN cDNA B230208H11 gene Neighboring gene STARR-seq mESC enhancer starr_25804 Neighboring gene STARR-positive B cell enhancer ABC_E2928 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon TAA) Neighboring gene STARR-positive B cell enhancer mm9_chr10:12683331-12683631 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:12684154-12684263 Neighboring gene STARR-positive B cell enhancer mm9_chr10:12716948-12717249 Neighboring gene STARR-positive B cell enhancer ABC_E5119 Neighboring gene predicted gene, 57557 Neighboring gene splicing factor 3b, subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice. Sepulveda FE, et al. Blood, 2015 Feb 26. PMID 25525117
    2. Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. D'Orlando O, et al. Eur J Immunol, 2013 Jan. PMID 23042080, Free PMC Article
    3. Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Offenhäuser C, et al. Traffic, 2011 Jun. PMID 21388490
    4. Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Kinoshita D, et al. Mol Biol Cell, 2019 Apr 15. PMID 30811271, Free PMC Article
    5. Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice. Sepulveda FE, et al. Blood, 2016 Apr 28. PMID 26864340

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
      Title: Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
    2. Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses.
      Title: Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages.
    3. required for NK and CD8+ T cell cytotoxicity and neutrophil degranulation
      Title: Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.
    4. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
      Title: Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
    5. Blockade of inhibitory receptors on T cells in Stx11-deficient mice converted nonfatal disease course into fatal HLH, identifying T-cell exhaustion as an important factor for determination of disease severity in hemophagocytic lymphohistiocytosis.
      Title: Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.
    6. Results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages.
      Title: Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages.
    7. Stx11 were highly expressed at the end of fetal development but downregulated at 4 and 11 weeks in brain, pancreas, and heart.
      Title: Developmental methylation program and concerted expression of Stx11 in mouse tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytotoxic T cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within natural killer cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163590.1 → NP_001157062.1  syntaxin-11

      See identical proteins and their annotated locations for NP_001157062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL691505
      Consensus CDS
      CCDS48500.1
      UniProtKB/Swiss-Prot
      Q9D3G5
      UniProtKB/TrEMBL
      Q3TAS3, Q3U5V8
      Related
      ENSMUSP00000132758.2, ENSMUST00000163425.9
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    2. NM_001163591.1 → NP_001157063.1  syntaxin-11

      See identical proteins and their annotated locations for NP_001157063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL691505
      Consensus CDS
      CCDS48500.1
      UniProtKB/Swiss-Prot
      Q9D3G5
      UniProtKB/TrEMBL
      Q3TAS3, Q3U5V8
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    3. NM_029075.1 → NP_083351.1  syntaxin-11

      See identical proteins and their annotated locations for NP_083351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK017897, AK153408, BY753247
      Consensus CDS
      CCDS48500.1
      UniProtKB/Swiss-Prot
      Q9D3G5
      UniProtKB/TrEMBL
      Q3TAS3, Q3U5V8
      Related
      ENSMUSP00000046243.6, ENSMUST00000042861.7
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      12813961..12840242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512886.4 → XP_006512949.1  syntaxin-11 isoform X1

      See identical proteins and their annotated locations for XP_006512949.1

      UniProtKB/Swiss-Prot
      Q9D3G5
      UniProtKB/TrEMBL
      Q3TAS3, Q3U5V8
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    2. XM_006512887.4 → XP_006512950.1  syntaxin-11 isoform X1

      See identical proteins and their annotated locations for XP_006512950.1

      UniProtKB/Swiss-Prot
      Q9D3G5
      UniProtKB/TrEMBL
      Q3TAS3, Q3U5V8
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif

    3. XM_006512888.5 → XP_006512951.1  syntaxin-11 isoform X1

      See identical proteins and their annotated locations for XP_006512951.1

      UniProtKB/Swiss-Prot
      Q9D3G5
      UniProtKB/TrEMBL
      Q3TAS3, Q3U5V8
      Conserved Domains (2) summary
      pfam00804
      Location:41 → 238
      Syntaxin
      cl22856
      Location:207 → 273
      SNARE; SNARE motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3G5.1 GenPept UniProtKB/Swiss-Prot:Q9D3G5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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