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    NPBWR1 neuropeptides B and W receptor 1 [ Homo sapiens (human) ]

    Gene ID: 2831, updated on 11-Apr-2024

    Summary

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    Official Symbol
    NPBWR1provided by HGNC
    Official Full Name
    neuropeptides B and W receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4522
    See related
    Ensembl:ENSG00000288611 MIM:600730; AllianceGenome:HGNC:4522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR7
    Summary
    Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See NPBWR1 in Genome Data Viewer
    Location:
    8q11.23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (52939182..52943734)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (53315605..53320157)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (53851742..53856294)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375835 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:53676283-53677482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27349 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:53764919-53765152 Neighboring gene uncharacterized LOC107986943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:53851917-53852548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53852549-53853180 Neighboring gene NANOG hESC enhancer GRCh37_chr8:53883082-53883583 Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53930926-53931660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53931661-53932394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:54055436-54056635 Neighboring gene uncharacterized LOC105375836 Neighboring gene EI24 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects. Pelosini C, et al. J Endocrinol Invest, 2013 Oct. PMID 23563248
    2. A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions. Watanabe N, et al. PLoS One, 2012. PMID 22545105, Free PMC Article
    3. Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies. Zaratin PF, et al. Mol Cell Neurosci, 2005 Jan. PMID 15607941
    4. Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. Cottrell S, et al. J Urol, 2007 May. PMID 17437806
    5. The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. O'Dowd BF, et al. Genomics, 1995 Jul 1. PMID 7590751

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that is fairly common in the study population. This variant is unlikely to cause a functional derangement of the receptor
      Title: Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.
    2. hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer
      Title: A prognostic DNA methylation signature for stage I non-small-cell lung cancer.
    3. A single nucleotide polymorphism of NPBWR1 changed the receptor function of this molecule at the cellular level, and, at the behavioral level, could influence personality difference in the context of social interaction.
      Title: A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.
    4. distribution in central nervous system and peripheral tissues with precursor peptides
      Title: Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.
    5. Expressed in the zona glomerulosa and zona fasciculata-reticularis ( cells of the human adrenal cortex.
      Title: G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
    6. neuropeptide B, a neuropeptide modified with bromine is an endogenous ligand for GPR7
      Title: Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.
    7. methylation of the GPR7 is significantly associated with prostate cancer prognosis.
      Title: Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.
    8. These results suggest a relationship between the pathogenesis of inflammatory/immune-mediated neuropathies, GPR7 receptor expression, and pain transmission.
      Title: Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.
    9. characterization of a family of endogenous neuropeptide ligands for this G protein-coupled receptor
      Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129755

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled opioid receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled opioid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuropeptides B/W receptor type 1
    Names
    G-protein coupled receptor 7
    neuropeptide B/W receptor 1
    neuropeptides B/W receptor 1
    opioid-somatostatin-like receptor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005285.5 → NP_005276.2  neuropeptides B/W receptor type 1

      See identical proteins and their annotated locations for NP_005276.2

      Status: VALIDATED

      Source sequence(s)
      AC087348
      Consensus CDS
      CCDS6151.1
      UniProtKB/Swiss-Prot
      P48145, Q6NTC7
      UniProtKB/TrEMBL
      H9NIL7
      Related
      ENSP00000501711.1, ENST00000674939.1
      Conserved Domains (1) summary
      cd15087
      Location:47 → 318
      7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      52939182..52943734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      53315605..53320157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48145.2 GenPept UniProtKB/Swiss-Prot:P48145

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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