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    Itih1 inter-alpha trypsin inhibitor, heavy chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306251, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Itih1provided by RGD
    Official Full Name
    inter-alpha trypsin inhibitor, heavy chain 1provided by RGD
    Primary source
    RGD:1306099
    See related
    Ensembl:ENSRNOG00000033386 AllianceGenome:RGD:1306099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of endopeptidase activity. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular matrix. Orthologous to human ITIH1 (inter-alpha-trypsin inhibitor heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 3969.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itih1 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6128696..6142813, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6122246..6136363, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7012376..7026542, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene NIMA-related kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene G protein nucleolar 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats. Disdier C, et al. Int J Dev Neurosci, 2018 Apr. PMID 29079121, Free PMC Article
    2. PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion. Scarchilli L, et al. J Biol Chem, 2007 Oct 12. PMID 17675295
    3. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that Alterations in Itih1 expression after hypoxic-ischemic brain injury in neonatal rats
      Title: Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107291.2 → NP_001100761.2  inter-alpha-trypsin inhibitor heavy chain H1 precursor

      See identical proteins and their annotated locations for NP_001100761.2

      Status: VALIDATED

      Source sequence(s)
      BC166831
      UniProtKB/TrEMBL
      A6KG18, B2RYM3
      Related
      ENSRNOP00000041165.3, ENSRNOT00000051751.4
      Conserved Domains (4) summary
      smart00609
      Location:33 → 160
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:283 → 464
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:52 → 602
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam06668
      Location:699 → 884
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6128696..6142813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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