NMI N-myc and STAT interactor [Homo sapiens (human)] - Gene

Summary

Official Symbol: NMIprovided by HGNC
Official Full Name: N-myc and STAT interactorprovided by HGNC
Primary source: HGNC:HGNC:7854
See related: Ensembl:ENSG00000123609 MIM:603525; AllianceGenome:HGNC:7854
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in appendix (RPKM 16.7), bone marrow (RPKM 15.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q23.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (151270470..151289668, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (151722213..151741416, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (152126984..152146182, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Title: NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction.
Title: N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction.
IFP35 family proteins promote neuroinflammation and multiple sclerosis.
Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
NMI promotes cell proliferation through TGFbeta/Smad pathway by upregulating STAT1 in colorectal cancer.
Title: NMI promotes cell proliferation through TGFβ/Smad pathway by upregulating STAT1 in colorectal cancer.
Elevated serum NMI (>/= 198.5 pg/mL) was correlated with poor survival rate of acute-on-chronic liver failure of hepatitis B virus patients.
Title: N-myc and STAT interactor correlates with severity and prognosis in acute-on-chronic liver failure of hepatitis B virus.
Negatively Regulates TNF-alpha-Induced NF-kappaB Transcriptional Activity by Sequestering NF-kappaB/p65 in the Cytoplasm
Title: N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm.
NMI and RAC1 might represent two new key genes related to gastric cancer
Title: Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations.
Nmi has a distinct role in the differentiation process of mammary luminal epithelial cell compartment and developmental aberrations resulting from Nmi absence contribute to metastasis.
Title: Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.
These results revealed that IRF-1 is involved in the IFN-inducible expression of Nmi.
Title: Interferon activates promoter of Nmi gene via interferon regulator factor-1.
Our study showed that NMI suppressed tumor growth by inhibiting PI3K/AKT, MMP2/MMP9, COX-2/PGE2 signaling pathways and p300-mediated NF-kappaB acetylation, and predicted a favorable prognosis in human lung adenocarcinomas, suggesting that NMI was a potential tumor suppressor in lung cancer.
Title: Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat downregulates N-myc (and STAT) interactor in HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interferon-alpha production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: N-myc-interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004688.3 → NP_004679.2 N-myc-interactor

See identical proteins and their annotated locations for NP_004679.2

Status: REVIEWED

Source sequence(s)

BC001268, BC021987, CB151555

Consensus CDS

CCDS2192.1

UniProtKB/Swiss-Prot

B5BU69, Q13287, Q53TI8, Q8WTW2, Q9BVE5

UniProtKB/TrEMBL

A8K683

Related

ENSP00000243346.5, ENST00000243346.10

Conserved Domains (3) summary

cd12544
Location:157 → 237

RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins

pfam07292
Location:203 → 291

NID; Nmi/IFP 35 domain (NID)

pfam07334
Location:29 → 104

IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

151270470..151289668 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005246941.3 → XP_005246998.1 N-myc-interactor isoform X2

See identical proteins and their annotated locations for XP_005246998.1

UniProtKB/Swiss-Prot

B5BU69, Q13287, Q53TI8, Q8WTW2, Q9BVE5

UniProtKB/TrEMBL

A8K683

Conserved Domains (3) summary

cd12544
Location:157 → 237

RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins

pfam07292
Location:203 → 291

NID; Nmi/IFP 35 domain (NID)

pfam07334
Location:29 → 104

IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
XM_047446270.1 → XP_047302226.1 N-myc-interactor isoform X1