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    Ziz Zizimin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34030, updated on 10-May-2024

    Summary

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    Official Symbol
    Zizprovided by FlyBase
    Official Full Name
    Ziziminprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260486
    Locus tag
    Dmel_CG42533
    See related
    AllianceGenome:FB:FBgn0260486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH71439; CG15819; CG42533; CG6630; Dm ziz; Dmel\CG42533
    Old locus tag
    Dmel_CG15819; Dmel_CG6630
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in compound eye development. Is expressed in adult head and spermatozoon. Orthologous to human DOCK10 (dedicator of cytokinesis 10); DOCK11 (dedicator of cytokinesis 11); and DOCK9 (dedicator of cytokinesis 9). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    28A1-28A4; 2-27 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7472513..7496307, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7472513..7496307, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 28b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rap GTPase activating protein 1 Neighboring gene Odorant-binding protein 28a Neighboring gene long non-coding RNA:CR44082

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila DOCK Family Protein Zizimin Involves in Pigment Cell Differentiation in Pupal Retinae. Ozasa F, et al. Cell Struct Funct, 2017 Aug 26. PMID 28701658
    2. CZH proteins: a new family of Rho-GEFs. Meller N, et al. J Cell Sci, 2005 Nov 1. PMID 16254241
    3. The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42. Sampson CJ, et al. Dev Comp Immunol, 2012 Sep. PMID 22634526
    4. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
    5. The Genetic Architecture of Ovariole Number in Drosophila melanogaster: Genes with Major, Quantitative, and Pleiotropic Effects. Lobell AS, et al. G3 (Bethesda), 2017 Jul 5. PMID 28550012, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    zizimin
    Names
    CG42533-PB
    CG42533-PC
    CG42533-PD
    CG42533-PE
    CG42533-PG
    CG42533-PH
    CG42533-PI
    CG42533-PJ
    CG42533-PK
    Dm zizimin
    Ziz-PB
    Ziz-PC
    Ziz-PD
    Ziz-PE
    Ziz-PG
    Ziz-PH
    Ziz-PI
    Ziz-PJ
    Ziz-PK
    zizimin ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7472513..7496307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273277.1 → NP_001260206.1  zizimin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF31
      Conserved Domains (5) summary
      cd08697
      Location:793 → 981
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:278 → 405
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:283 → 393
      PH; PH domain
      pfam06920
      Location:1748 → 2230
      DHR-2; Dock homology region 2
      pfam11878
      Location:54 → 81
      DUF3398; Domain of unknown function (DUF3398)

    2. NM_001273271.1 → NP_001260200.1  zizimin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCG3
      Conserved Domains (5) summary
      cd08697
      Location:793 → 981
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:278 → 405
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:283 → 393
      PH; PH domain
      pfam06920
      Location:1751 → 2233
      DHR-2; Dock homology region 2
      pfam11878
      Location:54 → 81
      DUF3398; Domain of unknown function (DUF3398)

    3. NM_135281.4 → NP_609125.4  zizimin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609125.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM04
      Conserved Domains (5) summary
      cd08697
      Location:793 → 981
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:278 → 405
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:283 → 393
      PH; PH domain
      pfam06920
      Location:1751 → 2233
      DHR-2; Dock homology region 2
      pfam11878
      Location:54 → 81
      DUF3398; Domain of unknown function (DUF3398)

    4. NM_001273275.1 → NP_001260204.1  zizimin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU9
      Conserved Domains (5) summary
      cd08697
      Location:793 → 982
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:278 → 405
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:283 → 393
      PH; PH domain
      pfam06920
      Location:1749 → 2231
      DHR-2; Dock homology region 2
      pfam11878
      Location:54 → 81
      DUF3398; Domain of unknown function (DUF3398)

    5. NM_001273273.1 → NP_001260202.1  zizimin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260202.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB64
      Conserved Domains (5) summary
      cd08697
      Location:793 → 982
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:278 → 405
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:283 → 393
      PH; PH domain
      pfam06920
      Location:1752 → 2234
      DHR-2; Dock homology region 2
      pfam11878
      Location:54 → 81
      DUF3398; Domain of unknown function (DUF3398)

    6. NM_001273278.1 → NP_001260207.1  zizimin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB65
      Conserved Domains (5) summary
      cd08697
      Location:807 → 995
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:292 → 419
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:297 → 407
      PH; PH domain
      pfam06920
      Location:1762 → 2244
      DHR-2; Dock homology region 2
      pfam11878
      Location:68 → 95
      DUF3398; Domain of unknown function (DUF3398)

    7. NM_001273274.1 → NP_001260203.1  zizimin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCA8
      Conserved Domains (5) summary
      cd08697
      Location:807 → 995
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:292 → 419
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:297 → 407
      PH; PH domain
      pfam06920
      Location:1765 → 2247
      DHR-2; Dock homology region 2
      pfam11878
      Location:68 → 95
      DUF3398; Domain of unknown function (DUF3398)

    8. NM_001273272.1 → NP_001260201.1  zizimin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF26
      Conserved Domains (5) summary
      cd08697
      Location:807 → 996
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:292 → 419
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:297 → 407
      PH; PH domain
      pfam06920
      Location:1763 → 2245
      DHR-2; Dock homology region 2
      pfam11878
      Location:68 → 95
      DUF3398; Domain of unknown function (DUF3398)

    9. NM_001273276.1 → NP_001260205.1  zizimin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCG7
      Conserved Domains (5) summary
      cd08697
      Location:807 → 996
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:292 → 419
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:297 → 407
      PH; PH domain
      pfam06920
      Location:1766 → 2248
      DHR-2; Dock homology region 2
      pfam11878
      Location:68 → 95
      DUF3398; Domain of unknown function (DUF3398)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB64 M9PB64
    M9PB65 M9PB65
    M9PCA8 M9PCA8
    M9PCG3 M9PCG3
    M9PCG7 M9PCG7
    M9PCU9 M9PCU9
    M9PF26 M9PF26
    M9PF31 M9PF31
    Q8MYS5 Q8MYS5
    Q9VM04 Q9VM04

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