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    Arhgef19 Rho guanine nucleotide exchange factor 19 [ Mus musculus (house mouse) ]

    Gene ID: 213649, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Arhgef19provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 19provided by MGI
    Primary source
    MGI:MGI:1925912
    See related
    Ensembl:ENSMUSG00000028919 AllianceGenome:MGI:1925912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WGEF; 6030432F23; 6430573B13Rik
    Summary
    Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within positive regulation of GTPase activity and wound healing. Is expressed in several structures, including genitourinary system; nose; oral epithelium; pharyngo-tympanic tube; and vibrissa. Orthologous to human ARHGEF19 (Rho guanine nucleotide exchange factor 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 12.6), duodenum adult (RPKM 12.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 73.53 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140966916..140985226)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141239605..141257915)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3534 Neighboring gene F-box protein 42 Neighboring gene STARR-seq mESC enhancer starr_11892 Neighboring gene STARR-positive B cell enhancer ABC_E10273 Neighboring gene STARR-positive B cell enhancer ABC_E3535 Neighboring gene STARR-positive B cell enhancer ABC_E6249 Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene RIKEN cDNA C630004L07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:140795314-140795615 Neighboring gene predicted gene, 52686 Neighboring gene STARR-seq mESC enhancer starr_11896 Neighboring gene STARR-seq mESC enhancer starr_11899 Neighboring gene predicted gene 13056 Neighboring gene STARR-seq mESC enhancer starr_11901 Neighboring gene Eph receptor A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF. Horii T, et al. PLoS One, 2009 Jun 5. PMID 19503838, Free PMC Article
    2. WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney. Wang Y, et al. Biochem Biophys Res Commun, 2004 Nov 19. PMID 15485661
    3. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Tsuji T, et al. Mol Biol Cell, 2010 Oct 15. PMID 20810787, Free PMC Article
    4. Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis. Kimura-Yoshida C, et al. Nat Commun, 2018 Oct 3. PMID 30283008, Free PMC Article
    5. Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Caddy J, et al. Dev Cell, 2010 Jul 20. PMID 20643356, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. adipogenesis is regulated by WGEF expression through DNA methylation change
      Title: Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF.
    2. WGEF is a RhoGEF expressed in intestine, liver, heart, and kidney
      Title: WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 19
    Names
    Rho guanine nucleotide exchange factor (GEF) 19
    ephexin-2
    weakly similar to Rho GEF 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379647.1 → NP_001366576.1  rho guanine nucleotide exchange factor 19

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AL607087
      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily

    2. NM_001379652.1 → NP_001366581.1  rho guanine nucleotide exchange factor 19

      Status: VALIDATED

      Source sequence(s)
      AL607087
      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily

    3. NM_172520.3 → NP_766108.1  rho guanine nucleotide exchange factor 19

      See identical proteins and their annotated locations for NP_766108.1

      Status: VALIDATED

      Source sequence(s)
      AL607087
      Consensus CDS
      CCDS18868.1
      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Related
      ENSMUSP00000006618.3, ENSMUST00000006618.9
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      140966916..140985226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250225.3 → XP_011248527.1  rho guanine nucleotide exchange factor 19 isoform X1

      See identical proteins and their annotated locations for XP_011248527.1

      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily

    2. XM_006538705.2 → XP_006538768.1  rho guanine nucleotide exchange factor 19 isoform X1

      See identical proteins and their annotated locations for XP_006538768.1

      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily

    3. XM_017320098.1 → XP_017175587.1  rho guanine nucleotide exchange factor 19 isoform X1

      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily

    4. XM_006538709.5 → XP_006538772.1  rho guanine nucleotide exchange factor 19 isoform X1

      See identical proteins and their annotated locations for XP_006538772.1

      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily

    5. XM_006538708.4 → XP_006538771.1  rho guanine nucleotide exchange factor 19 isoform X1

      See identical proteins and their annotated locations for XP_006538771.1

      UniProtKB/Swiss-Prot
      Q6PAC2, Q8BWA8
      Conserved Domains (3) summary
      cd01221
      Location:580 → 706
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:382 → 558
      RhoGEF; RhoGEF domain
      cl17036
      Location:719 → 773
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWA8.1 GenPept UniProtKB/Swiss-Prot:Q8BWA8

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