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    Gpr176 G protein-coupled receptor 176 [ Mus musculus (house mouse) ]

    Gene ID: 381413, updated on 12-May-2024

    Summary

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    Official Symbol
    Gpr176provided by MGI
    Official Full Name
    G protein-coupled receptor 176provided by MGI
    Primary source
    MGI:MGI:2685858
    See related
    Ensembl:ENSMUSG00000040133 AllianceGenome:MGI:2685858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1012
    Summary
    Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and circadian behavior. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in brain and genitourinary system. Orthologous to human GPR176 (G protein-coupled receptor 176). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 1.1), CNS E18 (RPKM 1.0) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr176 in Genome Data Viewer
    Location:
    2 E5; 2 59.4 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118107577..118205022, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118277096..118374549, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene thrombospondin 1 Neighboring gene fibrous sheath-interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_05456 Neighboring gene STARR-positive B cell enhancer ABC_E7849 Neighboring gene STARR-positive B cell enhancer mm9_chr2:118089004-118089305 Neighboring gene STARR-seq mESC enhancer starr_05457 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene STARR-seq mESC enhancer starr_05459 Neighboring gene STARR-positive B cell enhancer ABC_E1594 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E9525 Neighboring gene signal recognition particle 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176. Wang T, et al. Sci Rep, 2020 Mar 10. PMID 32157140, Free PMC Article
    2. Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity. Yamaguchi Y, et al. Biol Pharm Bull, 2022. PMID 35908898
    3. GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer. Tang J, et al. Adv Sci (Weinh), 2023 Apr. PMID 36905238, Free PMC Article
    4. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Doi M, et al. Nat Commun, 2016 Feb 17. PMID 26882873, Free PMC Article
    5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
      Title: GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
    2. Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
      Title: Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
    3. Gpr176 is an suprachiasmatic nucleus-enriched orphan G-protein-coupled receptors that sets the pace of circadian behavior.
      Title: Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC62396

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 176
    Names
    G-protein coupled receptor AGR9
    probable G-protein coupled receptor 176

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201367.3 → NP_958755.1  G-protein coupled receptor 176

      See identical proteins and their annotated locations for NP_958755.1

      Status: VALIDATED

      Source sequence(s)
      AL845495, AL929163
      Consensus CDS
      CCDS16575.1
      UniProtKB/Swiss-Prot
      Q80UC4, Q80WT4
      Related
      ENSMUSP00000037586.3, ENSMUST00000039160.3
      Conserved Domains (1) summary
      pfam00001
      Location:57 → 318
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118107577..118205022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251820.2 → XP_030107680.1  G-protein coupled receptor 176 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:4 → 34
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 218
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_011239648.3 → XP_011237950.1  G-protein coupled receptor 176 isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:16 → 42
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:1 → 271
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WT4.1 GenPept UniProtKB/Swiss-Prot:Q80WT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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