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    USP29 ubiquitin specific peptidase 29 [ Homo sapiens (human) ]

    Gene ID: 57663, updated on 5-Mar-2024

    Summary

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    Official Symbol
    USP29provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 29provided by HGNC
    Primary source
    HGNC:HGNC:18563
    See related
    Ensembl:ENSG00000131864 MIM:609546; AllianceGenome:HGNC:18563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOM-TES-84/86
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in G1/S transition of mitotic cell cycle and protein deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 2.8) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57119087..57131926)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60215749..60228591)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57630455..57643294)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372475 Neighboring gene Sharpr-MPRA regulatory region 3098 Neighboring gene zinc finger protein 300 pseudogene Neighboring gene small nucleolar RNA U3 Neighboring gene zinc finger imprinted 3 Neighboring gene DPPA3 pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b. Gao W, et al. mBio, 2022 Jun 28. PMID 35638730, Free PMC Article
    2. USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation. Hernández-Reyes Y, et al. Cells, 2022 Aug 11. PMID 36010569, Free PMC Article
    3. USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis. Gao R, et al. Oncogenesis, 2021 Jul 16. PMID 34272356, Free PMC Article
    4. Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis. Chandrasekaran AP, et al. Int J Mol Sci, 2021 May 28. PMID 34071237, Free PMC Article
    5. USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination. Martín Y, et al. Oncogene, 2015 Feb 19. PMID 24632611

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
      Title: Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
    2. The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b.
      Title: The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b.
    3. USP29 coordinates MYC and HIF1alpha stabilization to promote tumor metabolism and progression.
      Title: USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression.
    4. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
      Title: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
    5. Self-stabilizing regulation of deubiquitinating enzymes in an enzymatic activity-dependent manner.
      Title: Self-stabilizing regulation of deubiquitinating enzymes in an enzymatic activity-dependent manner.
    6. Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
      Title: Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
    7. Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
      Title: Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
    8. USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.
      Title: USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC163266, MGC163270

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 29
    Names
    deubiquitinating enzyme 29
    ubiquitin thioesterase 29
    ubiquitin thiolesterase 29
    ubiquitin-specific processing protease
    ubiquitin-specific-processing protease 29
    NP_001376572.1
    NP_065954.1
    XP_024307392.1
    XP_054177532.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389643.1 → NP_001376572.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC025588
      Consensus CDS
      CCDS33124.1
      UniProtKB/Swiss-Prot
      Q9HBJ7
      Related
      ENSP00000470747.1, ENST00000598197.1
      Conserved Domains (3) summary
      cd02257
      Location:823 → 883
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cd13312
      Location:4 → 106
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:286 → 552
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001426405.1 → NP_001413334.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CP068259
      UniProtKB/TrEMBL
      A1L447

    3. NM_001426406.1 → NP_001413335.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CP068259
      UniProtKB/TrEMBL
      A1L447

    4. NM_020903.3 → NP_065954.1  ubiquitin carboxyl-terminal hydrolase 29 isoform 1

      See identical proteins and their annotated locations for NP_065954.1

      Status: VALIDATED

      Source sequence(s)
      AC025588
      Consensus CDS
      CCDS33124.1
      UniProtKB/Swiss-Prot
      Q9HBJ7
      Related
      ENSP00000254181.3, ENST00000254181.9
      Conserved Domains (3) summary
      cd02257
      Location:823 → 883
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cd13312
      Location:4 → 106
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:286 → 552
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57119087..57131926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451624.2 → XP_024307392.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

      UniProtKB/Swiss-Prot
      Q9HBJ7
      Conserved Domains (3) summary
      cd02257
      Location:823 → 883
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cd13312
      Location:4 → 106
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:286 → 552
      UCH; Ubiquitin carboxyl-terminal hydrolase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60215749..60228591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321557.1 → XP_054177532.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X2

      UniProtKB/TrEMBL
      A1L447
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBJ7.1 GenPept UniProtKB/Swiss-Prot:Q9HBJ7

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