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    Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60433, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rfngprovided by RGD
    Official Full Name
    RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by RGD
    Primary source
    RGD:621322
    See related
    Ensembl:ENSRNOG00000050298 AllianceGenome:RGD:621322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in negative regulation of Notch signaling pathway. Predicted to be integral component of Golgi membrane. Orthologous to human RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 128.9), Kidney (RPKM 78.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rfng in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106545543..106548644, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106047221..106050331, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109963726..109966821, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A, pseudogene 16 Neighboring gene carbonyl reductase 2 like 1 Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Radical fringe negatively modulates Notch signaling in postmitotic neurons of the rat brain. Mikami T, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165380
    2. Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Kakuda S, et al. Dev Cell, 2017 Jan 23. PMID 28089369, Free PMC Article
    3. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Yang LT, et al. Mol Biol Cell, 2005 Feb. PMID 15574878, Free PMC Article
    4. Cell and molecular biology of Notch. Fiúza UM, et al. J Endocrinol, 2007 Sep. PMID 17761886
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pattern specification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-N-acetylglucosaminyltransferase radical fringe
    Names
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    NP_068621.1
    XP_006247972.1
    XP_008766702.1
    XP_008766703.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021849.2 → NP_068621.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe

      See identical proteins and their annotated locations for NP_068621.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q9R1U9
      UniProtKB/TrEMBL
      A6HLJ4, A6HLJ5
      Conserved Domains (1) summary
      pfam02434
      Location:58 → 308
      Fringe; Fringe-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106545543..106548644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247910.5 → XP_006247972.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X2

      See identical proteins and their annotated locations for XP_006247972.1

      UniProtKB/TrEMBL
      A6HLJ3, Q6P6T7
      Conserved Domains (1) summary
      pfam02434
      Location:58 → 308
      Fringe; Fringe-like

    2. XM_008768480.4 → XP_008766702.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1

      UniProtKB/TrEMBL
      A6HLJ3, M0RD65
      Related
      ENSRNOP00000067562.2
      Conserved Domains (1) summary
      pfam02434
      Location:58 → 327
      Fringe; Fringe-like

    3. XM_008768481.4 → XP_008766703.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5T8, A6HLJ4
      Related
      ENSRNOP00000073554.2
      Conserved Domains (1) summary
      pfam02434
      Location:58 → 327
      Fringe; Fringe-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1U9.1 GenPept UniProtKB/Swiss-Prot:Q9R1U9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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