Pnma1 paraneoplastic antigen MA1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pnma1provided by MGI
Official Full Name: paraneoplastic antigen MA1provided by MGI
Primary source: MGI:MGI:2180564
See related: Ensembl:ENSMUSG00000054383 AllianceGenome:MGI:2180564
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730402C15Rik
Summary: Predicted to be involved in inflammatory response to antigenic stimulus. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Orthologous to human PNMA1 (PNMA family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 39.07 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (84192905..84195263, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (84146131..84148489, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PNMA1 functions to promote neuronal death. PNMA1-mediated apoptosis can be prevented by Bcl2. Although the detailed mechanism remains to be delineated, it is likely to involve association of proteins with PNMA1 through its BH3-like sequence.
Title: Induction of neuronal cell death by paraneoplastic Ma1 antigen.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493345

D12Mit254 (e-PCR), detects polymorphism
- UniSTS:126812

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paraneoplastic antigen Ma1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.