Tcim transcriptional and immune response regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcimprovided by MGI
Official Full Name: transcriptional and immune response regulatorprovided by MGI
Primary source: MGI:MGI:1916318
See related: Ensembl:ENSMUSG00000056313 AllianceGenome:MGI:1916318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110065B09Rik; 1810011O10Rik
Summary: Predicted to enable Notch binding activity. Acts upstream of or within regulation of hemopoiesis. Located in cytoplasm and nucleus. Is expressed in lower jaw molar; olfactory epithelium; and upper jaw molar. Orthologous to human TCIM (transcriptional and immune response regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 12.47 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (24927188..24928962, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (24437172..24438946, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data support that Tc1 is a novel regulator for adipose stem cells.
Title: Adipose tissue hyperplasia with enhanced adipocyte-derived stem cell activity in Tc1(C8orf4)-deleted mice.
Tc1 mice express sleep-related phenotypes that are comparable with those seen in Down syndrome patients
Title: Sleep-like behavior and 24-h rhythm disruption in the Tc1 mouse model of Down syndrome.
TC1 was involved in the mitogen-activated ERK1/2 signaling pathway and positively regulated G(1)- to S-phase transition of the cell cycle.[TC1]
Title: TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

AW321058 (e-PCR)
- UniSTS:179717

AW121743 (e-PCR)
- UniSTS:164374

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hemopoiesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional and immune response regulator

Names: protein C8orf4 homolog; thyroid cancer-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026931.3 → NP_081207.1 transcriptional and immune response regulator

Status: VALIDATED

Source sequence(s)

AC164300

Consensus CDS

CCDS22194.1

UniProtKB/Swiss-Prot

Q9D915

Related

ENSMUSP00000058631.5, ENSMUST00000052622.6

Conserved Domains (1) summary

pfam15063
Location:11 → 84

TC1; Thyroid cancer protein 1