Dnmt3b DNA methyltransferase 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnmt3bprovided by MGI
Official Full Name: DNA methyltransferase 3Bprovided by MGI
Primary source: MGI:MGI:1261819
See related: Ensembl:ENSMUSG00000027478 AllianceGenome:MGI:1261819
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MmuIIIB
Summary: This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.1), limb E14.5 (RPKM 1.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.79 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (153491332..153529650)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (153649411..153687730)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
Title: Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
FOXC1 Promotes Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells via the Dnmt3b/CXCL12 Axis.
Title: FOXC1 Promotes Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells via the Dnmt3b/CXCL12 Axis.
Dnmt3b ablation affects fracture repair process by regulating apoptosis.
Title: Dnmt3b ablation affects fracture repair process by regulating apoptosis.
DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression.
Title: DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression.
Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression.
Title: Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression.
Uterine deficiency of Dnmt3b impairs decidualization and causes consequent embryo implantation defects.
Title: Uterine deficiency of Dnmt3b impairs decidualization and causes consequent embryo implantation defects.
DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis.
Title: DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis.
Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis.
Title: Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis.
5-Methylcytosine and 5-Hydroxymethylcytosine in Scrapie-Infected Sheep and Mouse Brain Tissues.
Title: 5-Methylcytosine and 5-Hydroxymethylcytosine in Scrapie-Infected Sheep and Mouse Brain Tissues.
Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B.
Title: Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B.

Submit: New GeneRIF Correction See all GeneRIFs (138)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:516618

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:467533

UniSTS:472909 (e-PCR)
- UniSTS:472909

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:472909

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:467534

NoName (e-PCR)
- UniSTS:548451

NoName (e-PCR)
- UniSTS:548452

NoName (e-PCR)
- UniSTS:548453

NoName (e-PCR)
- UniSTS:548454

UniSTS:525685 (e-PCR)
- UniSTS:525685

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525685

UniSTS:525686 (e-PCR)
- UniSTS:525686

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525686

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525687

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525699

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA (cytosine-5-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	IBA Inferred from Biological aspect of Ancestor more info
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	IDA Inferred from Direct Assay more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates	TAS Traceable Author Statement more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within autosome genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in epigenetic programming of gene expression	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epigenetic programming of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gene silencing by piRNA-directed DNA methylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retrotransposon silencing by heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
part_of heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA (cytosine-5)-methyltransferase 3B

Names: DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB

NP_001003960.2

EC 2.1.1.37

NP_001003961.2

EC 2.1.1.37

NP_001003963.2

EC 2.1.1.37

NP_001116469.1

EC 2.1.1.37

NP_001258673.1

EC 2.1.1.37

NP_001258674.1

EC 2.1.1.37

NP_001258675.1

EC 2.1.1.37

NP_001258676.1

EC 2.1.1.37

NP_001403948.1

EC 2.1.1.37

NP_001403949.1

EC 2.1.1.37

NP_001403950.1

EC 2.1.1.37

NP_001403951.1

EC 2.1.1.37

NP_001403952.1

EC 2.1.1.37

NP_001403953.1

EC 2.1.1.37

NP_034198.3

EC 2.1.1.37

XP_006498745.1

EC 2.1.1.37

XP_006498746.1

EC 2.1.1.37

XP_006498747.1

EC 2.1.1.37

XP_006498748.1

EC 2.1.1.37

XP_006498749.1

EC 2.1.1.37

XP_006498750.1

EC 2.1.1.37

XP_006498751.1

EC 2.1.1.37

XP_030103075.1

EC 2.1.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003960.5 → NP_001003960.2 DNA (cytosine-5)-methyltransferase 3B isoform 2

See identical proteins and their annotated locations for NP_001003960.2

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16913.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000080334.7, ENSMUST00000081628.13

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001003961.5 → NP_001003961.2 DNA (cytosine-5)-methyltransferase 3B isoform 1

See identical proteins and their annotated locations for NP_001003961.2

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16914.1

UniProtKB/Swiss-Prot

O88509, O88510, O88511

Related

ENSMUSP00000105396.3, ENSMUST00000109774.9

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001003963.5 → NP_001003963.2 DNA (cytosine-5)-methyltransferase 3B isoform 4

See identical proteins and their annotated locations for NP_001003963.2

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16915.1

UniProtKB/TrEMBL

Q541E5

Related

ENSMUSP00000086370.6, ENSMUST00000088976.12

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001122997.3 → NP_001116469.1 DNA (cytosine-5)-methyltransferase 3B isoform 5

See identical proteins and their annotated locations for NP_001116469.1

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS50759.1

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000105393.2, ENSMUST00000109771.2

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:581 → 743

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271744.2 → NP_001258673.1 DNA (cytosine-5)-methyltransferase 3B isoform 1

See identical proteins and their annotated locations for NP_001258673.1

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16914.1

UniProtKB/Swiss-Prot

O88509, O88510, O88511

Related

ENSMUSP00000072761.4, ENSMUST00000072997.10

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271745.2 → NP_001258674.1 DNA (cytosine-5)-methyltransferase 3B isoform 2

See identical proteins and their annotated locations for NP_001258674.1

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16913.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000105395.2, ENSMUST00000109773.8

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271746.2 → NP_001258675.1 DNA (cytosine-5)-methyltransferase 3B isoform 4

See identical proteins and their annotated locations for NP_001258675.1

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16915.1

UniProtKB/TrEMBL

Q541E5

Related

ENSMUSP00000105394.2, ENSMUST00000109772.8

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271747.2 → NP_001258676.1 DNA (cytosine-5)-methyltransferase 3B isoform 3

See identical proteins and their annotated locations for NP_001258676.1

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16916.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000099440.2, ENSMUST00000103151.8

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001417019.1 → NP_001403948.1 DNA (cytosine-5)-methyltransferase 3B isoform 6

Status: REVIEWED

Source sequence(s)

AL929021
NM_001417020.1 → NP_001403949.1 DNA (cytosine-5)-methyltransferase 3B isoform 6

Status: REVIEWED

Source sequence(s)

AL929021
NM_001417021.1 → NP_001403950.1 DNA (cytosine-5)-methyltransferase 3B isoform 7

Status: REVIEWED

Source sequence(s)

AL929021
NM_001417022.1 → NP_001403951.1 DNA (cytosine-5)-methyltransferase 3B isoform 8

Status: REVIEWED

Source sequence(s)

AL929021
NM_001417023.1 → NP_001403952.1 DNA (cytosine-5)-methyltransferase 3B isoform 8

Status: REVIEWED

Source sequence(s)

AL929021
NM_001417024.1 → NP_001403953.1 DNA (cytosine-5)-methyltransferase 3B isoform 3

Status: REVIEWED

Source sequence(s)

AL929021
NM_010068.6 → NP_034198.3 DNA (cytosine-5)-methyltransferase 3B isoform 3

See identical proteins and their annotated locations for NP_034198.3

Status: REVIEWED

Source sequence(s)

AL929021

Consensus CDS

CCDS16916.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000099439.4, ENSMUST00000103150.10

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

153491332..153529650

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498684.4 → XP_006498747.1 DNA (cytosine-5)-methyltransferase 3B isoform X3

See identical proteins and their annotated locations for XP_006498747.1

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000051830.8, ENSMUST00000056495.14

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:581 → 743

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498682.1 → XP_006498745.1 DNA (cytosine-5)-methyltransferase 3B isoform X1

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:593 → 755

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498687.2 → XP_006498750.1 DNA (cytosine-5)-methyltransferase 3B isoform X7

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:593 → 755

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498683.1 → XP_006498746.1 DNA (cytosine-5)-methyltransferase 3B isoform X2

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:592 → 754

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498688.4 → XP_006498751.1 DNA (cytosine-5)-methyltransferase 3B isoform X8

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:592 → 754

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498685.2 → XP_006498748.1 DNA (cytosine-5)-methyltransferase 3B isoform X4

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:573 → 735

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:428 → 547

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498686.2 → XP_006498749.1 DNA (cytosine-5)-methyltransferase 3B isoform X5

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:572 → 734

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:428 → 547

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_030247215.2 → XP_030103075.1 DNA (cytosine-5)-methyltransferase 3B isoform X9

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:573 → 735

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:428 → 547

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)