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    Deaf1 Deformed epidermal autoregulatory factor-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40164, updated on 10-May-2024

    Summary

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    Official Symbol
    Deaf1provided by FlyBase
    Official Full Name
    Deformed epidermal autoregulatory factor-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0013799
    Locus tag
    Dmel_CG8567
    See related
    AllianceGenome:FB:FBgn0013799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8567; Deaf-1; DEAF-1; deaf1; DEAF1; Dmel\CG8567; l(3)76BDv
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in embryo development; regulation of immune response; and regulation of transcription, DNA-templated. Located in nucleus and polytene chromosome. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval nervous system; extended germ band embryo; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in Vulto-van Silfout-de Vries syndrome. Orthologous to human DEAF1 (DEAF1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Deaf1 in Genome Data Viewer
    Location:
    76D1-76D1; 3-46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19818174..19830686)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19811274..19823786)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene cycle Neighboring gene fibp Neighboring gene tricornered Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis. Wu L, et al. Discov Oncol, 2022 Dec 15. PMID 36520265, Free PMC Article
    2. A large-scale RNAi screen identifies Deaf1 as a regulator of innate immune responses in Drosophila. Kuttenkeuler D, et al. J Innate Immun, 2010. PMID 20375635
    3. Regulation by homeoproteins: a comparison of deformed-responsive elements. Pederson JA, et al. Genetics, 2000 Oct. PMID 11014815, Free PMC Article
    4. The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase. Geng W, et al. Genetics, 2000 Dec. PMID 11102376, Free PMC Article
    5. DEAF-1 regulates immunity gene expression in Drosophila. Reed DE, et al. Proc Natl Acad Sci U S A, 2008 Jun 17. PMID 18550807, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila.
      Title: A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila.
    2. DEAF-1 is a regulator of Drosophila immunity; it activates the expression of Mtk and Drs promoter.
      Title: DEAF-1 regulates immunity gene expression in Drosophila.
    3. effects of loss or gain of DEAF-1 function on Drosophila development
      Title: DEAF-1 function is essential for the early embryonic development of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deformed epidermal autoregulatory factor-1
    Names
    CG8567-PA
    CG8567-PB
    CG8567-PC
    CG8567-PD
    CG8567-PE
    Deaf1-PA
    Deaf1-PB
    Deaf1-PC
    Deaf1-PD
    Deaf1-PE
    deaf-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19818174..19830686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275140.1 → NP_001262069.1  deformed epidermal autoregulatory factor-1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24180
      UniProtKB/TrEMBL
      M9PD02
      Conserved Domains (2) summary
      smart00258
      Location:219 → 291
      SAND; SAND domain
      pfam01753
      Location:521 → 557
      zf-MYND; MYND finger

    2. NM_079445.3 → NP_524169.1  deformed epidermal autoregulatory factor-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524169.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24180
      UniProtKB/TrEMBL
      M9PD02
      Related
      FBpp0074651
      Conserved Domains (2) summary
      smart00258
      Location:219 → 291
      SAND; SAND domain
      pfam01753
      Location:521 → 557
      zf-MYND; MYND finger

    3. NM_001038944.2 → NP_001034033.1  deformed epidermal autoregulatory factor-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86LC7
      Conserved Domains (2) summary
      smart00258
      Location:219 → 291
      SAND; SAND domain
      pfam01753
      Location:518 → 554
      zf-MYND; MYND finger

    4. NM_001275139.1 → NP_001262068.1  deformed epidermal autoregulatory factor-1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH34
      Conserved Domains (2) summary
      smart00258
      Location:182 → 254
      SAND; SAND domain
      pfam01753
      Location:484 → 520
      zf-MYND; MYND finger

    5. NM_001275141.1 → NP_001262070.1  deformed epidermal autoregulatory factor-1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFP9
      Conserved Domains (2) summary
      smart00258
      Location:182 → 254
      SAND; SAND domain
      pfam01753
      Location:481 → 517
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    2211283A.1
    E8NH34 E8NH34
    M9PD02 M9PD02
    M9PFP9 M9PFP9
    Q24180.1 Q24180
    Q86LC7 Q86LC7

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