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    MAGEA11 MAGE family member A11 [ Homo sapiens (human) ]

    Gene ID: 4110, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MAGEA11provided by HGNC
    Official Full Name
    MAGE family member A11provided by HGNC
    Primary source
    HGNC:HGNC:6798
    See related
    Ensembl:ENSG00000185247 MIM:300344; AllianceGenome:HGNC:6798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT1.11; MAGE11; MAGE-11; MAGEA-11
    Summary
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 1.8) See more
    Orthologs
    all
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    Genomic context

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    See MAGEA11 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (149688193..149717268)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (147951770..147980829, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (148769859..148798928)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21045 Neighboring gene FRAXF repeat instability region Neighboring gene MAGE family member A11 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:148757169-148757709 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:148808885-148809420 Neighboring gene MAGE family member A10 pseudogene Neighboring gene MAGE family member A11 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced Apoptosis in the in vitro Model of Prostate Cancer. Farhadi L, et al. Gulf J Oncolog, 2023 Jan. PMID 36804154
    2. Demethylation-mediated upregulation of melanoma-associated antigen-A11 correlates with malignant progression of esophageal squamous cell carcinoma. Gu L, et al. Dig Liver Dis, 2019 Oct. PMID 31155488
    3. Evolution of Melanoma Antigen-A11 (MAGEA11) During Primate Phylogeny. Willett CS, et al. J Mol Evol, 2018 Apr. PMID 29574604
    4. Prognostic Significance of MAGE-A11 in Esophageal Squamous Cell Carcinoma and Identification of Related Genes Based on DNA Microarray. Sang M, et al. Arch Med Res, 2016 Apr. PMID 27362547
    5. DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11. James SR, et al. Epigenetics, 2013 Aug. PMID 23839233, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced Apoptosis in the in vitro Model of Prostate Cancer.
      Title: The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced Apoptosis in the in vitro Model of Prostate Cancer.
    2. Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b.
      Title: Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b.
    3. Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
      Title: Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
    4. Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
      Title: Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
    5. Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
      Title: Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
    6. High MAGE-A11 expression is associated with tumorigenesis.
      Title: A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.
    7. AR and MAGEA11 associate in a molecular complex.
      Title: Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11.
    8. Significant up-regulation of melanoma-associated antigen-A11 was detected in esophageal cancer cell lines and esophageal squamous cell carcinoma tissues. Up-regulation of melanoma-associated antigen-A11 contributed to proliferation and invasion in cancer cells.
      Title: Demethylation-mediated upregulation of melanoma-associated antigen-A11 correlates with malignant progression of esophageal squamous cell carcinoma.
    9. MAGE-A11 and transcription factors SP1,TFCP2 and ZEB1 expression were associated with some clinical features in patients, such as pathological differentiation, tumor size, clinical stage, lymph node metastasis and distant metastasis. Patients with ESCC having high MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) expression had a worse prognosis compared to the patients with low expression.
      Title: Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues.
    10. SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity.
      Title: Androgen receptor regulation by histone methyltransferase Suppressor of variegation 3-9 homolog 2 and Melanoma antigen-A11.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC10511

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen 11
    Names
    MAGE-11 antigen
    cancer/testis antigen 1.11
    cancer/testis antigen family 1, member 11
    melanoma antigen family A, 11
    melanoma antigen family A11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012803.2 RefSeqGene

      Range
      28869..34077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001011544.2 → NP_001011544.1  melanoma-associated antigen 11 isoform b

      See identical proteins and their annotated locations for NP_001011544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC244197, AI691089, BC004479, BX337921
      Consensus CDS
      CCDS94721.1
      UniProtKB/TrEMBL
      G5E962
      Related
      ENSP00000328177.4, ENST00000333104.8
      Conserved Domains (2) summary
      pfam01454
      Location:214 → 368
      MAGE; MAGE family
      pfam12440
      Location:86 → 175
      MAGE_N; Melanoma associated antigen family N terminal

    2. NM_005366.5 → NP_005357.2  melanoma-associated antigen 11 isoform a

      See identical proteins and their annotated locations for NP_005357.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC244098, AI691089, BC004479, BQ212898
      Consensus CDS
      CCDS48180.1
      UniProtKB/Swiss-Prot
      P43364, Q5ETU4, Q6ZRZ5
      Related
      ENSP00000347358.5, ENST00000355220.6
      Conserved Domains (2) summary
      pfam01454
      Location:243 → 397
      MAGE; MAGE family
      pfam12440
      Location:115 → 204
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      149688193..149717268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442106.1 → XP_047298062.1  melanoma-associated antigen 11 isoform X1

      UniProtKB/Swiss-Prot
      P43364, Q5ETU4, Q6ZRZ5

    2. XM_011531164.3 → XP_011529466.1  melanoma-associated antigen 11 isoform X2

      Conserved Domains (2) summary
      pfam01454
      Location:235 → 389
      MAGE; MAGE family
      pfam12440
      Location:107 → 196
      MAGE_N; Melanoma associated antigen family N terminal

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      147951770..147980829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327064.1 → XP_054183039.1  melanoma-associated antigen 11 isoform X1

      UniProtKB/Swiss-Prot
      P43364, Q5ETU4, Q6ZRZ5

    2. XM_054327065.1 → XP_054183040.1  melanoma-associated antigen 11 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43364.2 GenPept UniProtKB/Swiss-Prot:P43364

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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