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    Su(z)12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48071, updated on 10-May-2024

    Summary

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    Official Symbol
    Su(z)12provided by FlyBase
    Primary source
    FLYBASE:FBgn0020887
    Locus tag
    Dmel_CG8013
    See related
    AllianceGenome:FB:FBgn0020887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8013; Dmel\CG8013; l(3)76BDo; Su(z); su(z)12; Su(Z)12; SU(Z)12; Su(z)[12]; Suz(12); Suz12; SUZ12
    Summary
    Contributes to nucleosome binding activity. Involved in histone lysine methylation; negative regulation of response to gamma radiation; and neurogenesis. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in organism. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Su(z)12 in Genome Data Viewer
    Location:
    76D4-76D4; 3-46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19918242..19923462, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19911342..19916562, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Precursor RNA processing 3 Neighboring gene Mtr3 Neighboring gene Regulatory particle non-ATPase 1 Neighboring gene Prefoldin 6 Neighboring gene Grasp65

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. General transcriptional silencing by a Polycomb response element in Drosophila. Sengupta AK, et al. Development, 2004 May. PMID 15056613
    2. Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core. Sharaf A, et al. Life Sci Alliance, 2022 Jul. PMID 35440471, Free PMC Article
    3. In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ. Akkouche A, et al. PLoS Pathog, 2021 Jan. PMID 33471856, Free PMC Article
    4. Multidimensional Proteomics Identifies Declines in Protein Homeostasis and Mitochondria as Early Signals for Normal Aging and Age-associated Disease in Drosophila. Yang L, et al. Mol Cell Proteomics, 2019 Oct. PMID 31434710, Free PMC Article
    5. RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2. Alecki C, et al. Nat Commun, 2020 Apr 14. PMID 32286294, Free PMC Article

    See all (191) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chracterization of functionally critical SU(Z)12 elements, including key determinants of SU(Z)12-E(Z) communication.
      Title: Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo function.
    2. Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites.
      Title: Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites.
    3. Data show that SU(Z)12 and Heterochromatin Protein 1 (HP1) do not co-localize.
      Title: In vivo analysis of Drosophila SU(Z)12 function.
    4. A Pcl-PSC2 complex is the histone methyltransferase that generates the high levels of histone3-lysine27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state.
      Title: Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.
    5. The nucleosome-binding subunits Su(z)12 and Nurf55 anchor the E(z) enzyme on chromatin substrates, an essential process in maintaining HOX gene silencing during development.
      Title: Nucleosome binding and histone methyltransferase activity of Drosophila PRC2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in facultative heterochromatin formation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Su(z)12
    Names
    CG8013-PA
    CG8013-PB
    Su(z)12-PA
    Su(z)12-PB
    Suppressor-of-zeste-12
    suppressor of zeste 12
    suppressor of zeste[12]

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19918242..19923462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168826.2 → NP_730465.1  Su(z)12, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T9D8, Q9NJG9, Q9VW55
      Related
      FBpp0074686
      Conserved Domains (1) summary
      pfam09733
      Location:511 → 644
      VEFS-Box; VEFS-Box of polycomb protein

    2. NM_143802.3 → NP_652059.1  Su(z)12, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652059.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NJG9
      Related
      FBpp0074685
      Conserved Domains (1) summary
      pfam09733
      Location:511 → 644
      VEFS-Box; VEFS-Box of polycomb protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NJG9.1 Q9NJG9

    Gene LinkOut

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