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    nudC [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39879, updated on 10-May-2024

    Summary

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    Official Symbol
    nudCprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021768
    Locus tag
    Dmel_CG9710
    See related
    AllianceGenome:FB:FBgn0021768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9710; Dmel\CG9710; DnudC; NudC; NUDC; Q9VVA6
    Summary
    Predicted to enable unfolded protein binding activity. Involved in nucleus localization and positive regulation of dendrite morphogenesis. Located in cytoplasm. Is expressed in several structures, including embryonic head sensory system; embryonic/larval fat body; extended germ band embryo; head; and sensory nervous system primordium. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See nudC in Genome Data Viewer
    Location:
    73C5-73D1; 3-45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16804994..16819532)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16798094..16812632)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit e Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tumor susceptibility gene 101 Neighboring gene Zinc finger CCHC-type containing 7 Neighboring gene uncharacterized protein Neighboring gene kuduk

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear migration, nucleokinesis and lissencephaly. Morris NR, et al. Trends Cell Biol, 1998 Dec. PMID 9861667
    2. Characterization of DnudC, the Drosophila homolog of an Aspergillus gene that functions in nuclear motility. Cunniff J, et al. Mech Dev, 1997 Aug. PMID 9376324
    3. LIS1 and dynein motor function in neuronal migration and development. Wynshaw-Boris A, et al. Genes Dev, 2001 Mar 15. PMID 11274050
    4. PCID2, a subunit of the Drosophila TREX-2 nuclear export complex, is essential for both mRNA nuclear export and its subsequent cytoplasmic trafficking. Glukhova AA, et al. RNA Biol, 2021 Nov. PMID 33602059, Free PMC Article
    5. The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology. Wang X, et al. J Neurosci, 2015 Oct 21. PMID 26490864, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nucleus localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    nudC
    Names
    CG9710-PA
    CG9710-PB
    nudC-PA
    nudC-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16804994..16819532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259876.1 → NP_001246805.1  nudC, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYK7, Q9VVA6
      Conserved Domains (2) summary
      cd06492
      Location:173 → 259
      p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
      pfam14050
      Location:7 → 58
      Nudc_N; N-terminal conserved domain of Nudc

    2. NM_140666.4 → NP_648923.1  nudC, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYK7, Q9VVA6
      Related
      FBpp0075087
      Conserved Domains (2) summary
      cd06492
      Location:173 → 259
      p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
      pfam14050
      Location:7 → 58
      Nudc_N; N-terminal conserved domain of Nudc
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVA6.2 Q9VVA6

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