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    Ssr3 signal sequence receptor, gamma [ Mus musculus (house mouse) ]

    Gene ID: 67437, updated on 8-May-2024

    Summary

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    Official Symbol
    Ssr3provided by MGI
    Official Full Name
    signal sequence receptor, gammaprovided by MGI
    Primary source
    MGI:MGI:1914687
    See related
    Ensembl:ENSMUSG00000027828 AllianceGenome:MGI:1914687
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRAPG; 0610038P07Rik
    Summary
    Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in genitourinary system. Orthologous to human SSR3 (signal sequence receptor subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 100.6), limb E14.5 (RPKM 73.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 E1; 3 30.15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65287078..65299974, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (65379657..65392553, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, shaker-related subfamily, beta member 1 Neighboring gene RIKEN cDNA A330015K06 gene Neighboring gene STARR-seq mESC enhancer starr_07854 Neighboring gene RIKEN cDNA A730090N16 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:65123524-65123825 Neighboring gene STARR-positive B cell enhancer ABC_E517 Neighboring gene STARR-positive B cell enhancer ABC_E4545 Neighboring gene acyl-CoA synthetase family member 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07858 Neighboring gene STARR-seq mESC enhancer starr_07859 Neighboring gene predicted gene, 34576

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Translocon-associated protein subunit Trap-γ/Ssr3 is required for vascular network formation in the mouse placenta. Yamaguchi YL, et al. Dev Dyn, 2011 Feb. PMID 21246656
    2. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Breunig JJ, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18728187, Free PMC Article
    3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that Trap-gamma appears to be required for vascular network formation in murine placental development.
      Title: Translocon-associated protein subunit Trap-γ/Ssr3 is required for vascular network formation in the mouse placenta.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocon-associated protein subunit gamma
    Names
    SSR-gamma
    TRAP-gamma
    signal sequence receptor subunit gamma
    translocon-associated protein gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026155.3 → NP_080431.1  translocon-associated protein subunit gamma

      See identical proteins and their annotated locations for NP_080431.1

      Status: PROVISIONAL

      Source sequence(s)
      AC113279
      Consensus CDS
      CCDS17386.1
      UniProtKB/Swiss-Prot
      Q8C0Z8, Q9DCF9
      UniProtKB/TrEMBL
      Q4FK79
      Related
      ENSMUSP00000029414.6, ENSMUST00000029414.12
      Conserved Domains (1) summary
      pfam07074
      Location:12 → 183
      TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      65287078..65299974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCF9.1 GenPept UniProtKB/Swiss-Prot:Q9DCF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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