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    Grk3 G protein-coupled receptor kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 320129, updated on 12-May-2024

    Summary

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    Official Symbol
    Grk3provided by MGI
    Official Full Name
    G protein-coupled receptor kinase 3provided by MGI
    Primary source
    MGI:MGI:87941
    See related
    Ensembl:ENSMUSG00000042249 AllianceGenome:MGI:87941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adrbk2; Bark-2; Adrbk-2; 4833444A01Rik
    Summary
    Enables G protein-coupled receptor kinase activity. Predicted to be involved in several processes, including cellular protein metabolic process; desensitization of G protein-coupled receptor signaling pathway; and inositol phosphate metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in several cellular components, including Z disc; dendrite; and sperm midpiece. Is expressed in adrenal gland; alimentary system; nervous system; retina; and vibrissa. Orthologous to human GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 7.8), cerebellum adult (RPKM 7.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grk3 in Genome Data Viewer
    Location:
    5 F; 5 55.29 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113058344..113163518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112910478..113015660, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1731 Neighboring gene predicted gene, 30529 Neighboring gene STARR-seq mESC enhancer starr_14014 Neighboring gene myosin XVIIIb Neighboring gene RIKEN cDNA 1700095B10 gene Neighboring gene STARR-seq mESC enhancer starr_14016 Neighboring gene predicted gene, 22740 Neighboring gene predicted gene 43247 Neighboring gene crystallin, beta B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. Peppel K, et al. J Biol Chem, 1997 Oct 10. PMID 9325250
    2. Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. Rabjohns EM, et al. Cells, 2023 Mar 23. PMID 37048054, Free PMC Article
    3. G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. Brozowski JM, et al. Stem Cell Res Ther, 2022 Jan 29. PMID 35093170, Free PMC Article
    4. Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion. Abraham AD, et al. J Neurosci, 2018 Sep 12. PMID 30076211, Free PMC Article
    5. G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. Tarrant TK, et al. J Leukoc Biol, 2013 Dec. PMID 23935208, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.
      Title: Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.
    2. G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.
      Title: G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.
    3. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
      Title: Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-adrenergic receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in desensitization of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in desensitization of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inositol phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rhodopsin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 3
    Names
    adrenergic receptor kinase, beta 2
    beta ARK2
    beta-ARK-2
    beta-adrenergic receptor kinase 2
    NP_001272735.1
    NP_796052.2
    XP_036021101.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285806.1 → NP_001272735.1  G protein-coupled receptor kinase 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AI851927, AK076533, AK134672, AK141186, CJ104587
      UniProtKB/TrEMBL
      Q8BVT9
      Conserved Domains (5) summary
      cd01240
      Location:446 → 563
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      pfam00069
      Location:84 → 346
      Pkinase; Protein kinase domain
      pfam00169
      Location:453 → 540
      PH; PH domain
      cl02565
      Location:1 → 79
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:78 → 423
      PKc_like; Protein Kinases, catalytic domain

    2. NM_177078.4 → NP_796052.2  G protein-coupled receptor kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_796052.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI851927, AK076533, AK134672, CJ104587
      Consensus CDS
      CCDS19545.1
      UniProtKB/Swiss-Prot
      F8VPM8, Q3UYH7
      UniProtKB/TrEMBL
      Q8BVT9
      Related
      ENSMUSP00000070445.5, ENSMUST00000065167.9
      Conserved Domains (5) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:553 → 670
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      pfam00069
      Location:191 → 453
      Pkinase; Protein kinase domain
      pfam00169
      Location:560 → 647
      PH; PH domain
      cl21453
      Location:185 → 530
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113058344..113163518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165208.1 → XP_036021101.1  G protein-coupled receptor kinase 3 isoform X1

      Conserved Domains (3) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:517 → 634
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cl21453
      Location:185 → 494
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_389274.5 RNA Sequence

    2. XR_880393.4 RNA Sequence

    3. XR_880394.4 RNA Sequence

    4. XR_004942525.1 RNA Sequence

    5. XR_003955659.2 RNA Sequence

    6. XR_389275.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001035531.1: Suppressed sequence

      Description
      NM_001035531.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UYH7.2 GenPept UniProtKB/Swiss-Prot:Q3UYH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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