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    Mllt10 MLLT10, histone lysine methyltransferase DOT1L cofactor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361285, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mllt10provided by RGD
    Official Full Name
    MLLT10, histone lysine methyltransferase DOT1L cofactorprovided by RGD
    Primary source
    RGD:1310874
    See related
    Ensembl:ENSRNOG00000022249 AllianceGenome:RGD:1310874
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in histone H3-K14 acetylation and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 213.6), Thymus (RPKM 134.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17q12.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (85729964..85857791)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (80821870..80949349)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (84847660..84981134)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553115 Neighboring gene uncharacterized LOC108353137 Neighboring gene SKI/DACH domain containing 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene uncharacterized LOC108348596 Neighboring gene uncharacterized LOC134482756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Chaplin T, et al. Blood, 1995 Sep 15. PMID 7662954
    2. AF10-dependent transcription is enhanced by its interaction with FLRG. Forissier S, et al. Biol Cell, 2007 Oct. PMID 17868029
    3. hDOT1L links histone methylation to leukemogenesis. Okada Y, et al. Cell, 2005 Apr 22. PMID 15851025
    4. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Chen S, et al. Mol Cell, 2015 Oct 15. PMID 26439302, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein AF-10
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
    translocated to, 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012162.1 → NP_001012162.1  protein AF-10

      See identical proteins and their annotated locations for NP_001012162.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087128
      UniProtKB/TrEMBL
      F1M8I4, Q5PQL6
      Related
      ENSRNOP00000093341.1, ENSRNOT00000107584.1
      Conserved Domains (1) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      85729964..85857791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095942.2 → XP_038951870.2  protein AF-10 isoform X1

    2. XM_063276642.1 → XP_063132712.1  protein AF-10 isoform X2

    3. XM_063276654.1 → XP_063132724.1  protein AF-10 isoform X15

    4. XM_063276655.1 → XP_063132725.1  protein AF-10 isoform X16

    5. XM_063276643.1 → XP_063132713.1  protein AF-10 isoform X3

    6. XM_063276647.1 → XP_063132717.1  protein AF-10 isoform X7

    7. XM_063276648.1 → XP_063132718.1  protein AF-10 isoform X8

    8. XM_063276644.1 → XP_063132714.1  protein AF-10 isoform X4

    9. XM_063276652.1 → XP_063132722.1  protein AF-10 isoform X12

    10. XM_063276657.1 → XP_063132727.1  protein AF-10 isoform X19

    11. XM_063276658.1 → XP_063132728.1  protein AF-10 isoform X20

    12. XM_039095945.2 → XP_038951873.1  protein AF-10 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKY6, A0A8I5ZT80
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:717 → 780
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    13. XM_039095941.2 → XP_038951869.1  protein AF-10 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKY6, A0A8I5ZT80
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:717 → 780
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    14. XM_039095947.2 → XP_038951875.1  protein AF-10 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZT80
      Related
      ENSRNOP00000081577.1
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:685 → 748
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    15. XM_039095944.2 → XP_038951872.1  protein AF-10 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKY6, A0A8I5ZT80
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:717 → 780
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    16. XM_039095948.2 → XP_038951876.1  protein AF-10 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZT80
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd20901
      Location:662 → 725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:81 → 151
      PHD_SF; PHD finger superfamily

    17. XM_063276646.1 → XP_063132716.1  protein AF-10 isoform X6

    18. XM_063276649.1 → XP_063132719.1  protein AF-10 isoform X9

    19. XM_039095943.2 → XP_038951871.1  protein AF-10 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKY6, A0A8I5ZT80
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:717 → 780
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    20. XM_063276656.1 → XP_063132726.1  protein AF-10 isoform X18

    21. XM_039095950.2 → XP_038951878.1  protein AF-10 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZK97, F1M8I4
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    22. XM_063276651.1 → XP_063132721.1  protein AF-10 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GKM2

    23. XM_039095957.2 → XP_038951885.1  protein AF-10 isoform X14

      UniProtKB/TrEMBL
      F1M8I4
      Conserved Domains (2) summary
      cd20901
      Location:584 → 647
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:3 → 73
      PHD_SF; PHD finger superfamily

    24. XM_063276653.1 → XP_063132723.1  protein AF-10 isoform X14

    25. XM_039095955.2 → XP_038951883.1  protein AF-10 isoform X13

      UniProtKB/TrEMBL
      A6JM89, F1M8I4
      Conserved Domains (2) summary
      cd20901
      Location:598 → 661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 87
      PHD_SF; PHD finger superfamily

    26. XM_039095960.2 → XP_038951888.1  protein AF-10 isoform X17

      UniProtKB/TrEMBL
      F1M8I4
      Conserved Domains (2) summary
      cd20901
      Location:563 → 626
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 52
      PHD_SF; PHD finger superfamily

    27. XM_063276650.1 → XP_063132720.1  protein AF-10 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZK97

    28. XM_039095959.2 → XP_038951887.1  protein AF-10 isoform X14

      UniProtKB/TrEMBL
      F1M8I4
      Conserved Domains (2) summary
      cd20901
      Location:584 → 647
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:3 → 73
      PHD_SF; PHD finger superfamily

    29. XM_039095952.2 → XP_038951880.1  protein AF-10 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZK97, F1M8I4
      Related
      ENSRNOP00000033877.6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    30. XM_039095953.2 → XP_038951881.1  protein AF-10 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZK97, F1M8I4
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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