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    Abcc12 ATP-binding cassette, sub-family C member 12 [ Mus musculus (house mouse) ]

    Gene ID: 244562, updated on 9-May-2024

    Summary

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    Official Symbol
    Abcc12provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family C member 12provided by MGI
    Primary source
    MGI:MGI:2441679
    See related
    Ensembl:ENSMUSG00000036872 AllianceGenome:MGI:2441679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRP9; 4930467B22Rik
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in mitochondrion. Is expressed in brain; eye; immune system; reproductive system; and stomach. Orthologous to human ABCC12 (ATP binding cassette subfamily C member 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 25.1) See more
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    Genomic context

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    See Abcc12 in Genome Data Viewer
    Location:
    8 C3; 8 42.06 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87231197..87307317, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86504568..86580688, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33687 Neighboring gene predicted gene, 24490 Neighboring gene STARR-seq mESC enhancer starr_22180 Neighboring gene STARR-seq mESC enhancer starr_22182 Neighboring gene STARR-positive B cell enhancer ABC_E10515 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene predicted gene, 22305 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:89230711-89230912 Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene predicted gene 10638

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function. Chambers IG, et al. Proc Natl Acad Sci U S A, 2022 Feb 8. PMID 35121660, Free PMC Article
    2. Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm. Ono N, et al. Biochem J, 2007 Aug 15. PMID 17472575, Free PMC Article
    3. Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12. Shimizu H, et al. Gene, 2003 May 22. PMID 12801629
    4. Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms. Pham DH, et al. Gastroenterology, 2021 Jul. PMID 33771553, Free PMC Article
    5. Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Maher JM, et al. Drug Metab Dispos, 2005 Jul. PMID 15802388

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.
      Title: MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.
    2. Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms.
      Title: Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms.
    3. Full-length Mrp9 was detected only in testicular germ cells and mouse sperm. In mouse and boar sperm, Mrp9 localizes to the midpiece, a structure containing all sperm mitochondria.
      Title: Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 12
    Names
    ATP-binding cassette transporter sub-family C member 12
    ATP-binding cassette, sub-family C (CFTR/MRP), member 12
    multidrug resistance-associated protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172912.4 → NP_766500.3  ATP-binding cassette sub-family C member 12

      See identical proteins and their annotated locations for NP_766500.3

      Status: VALIDATED

      Source sequence(s)
      AC132147, AC159262
      Consensus CDS
      CCDS22502.1
      UniProtKB/Swiss-Prot
      B2RRF4, Q80WJ2, Q80WJ3, Q80WJ6, Q8C0P3
      Related
      ENSMUSP00000079014.4, ENSMUST00000080115.10
      Conserved Domains (1) summary
      TIGR00957
      Location:43 → 1366
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      87231197..87307317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530984.4 → XP_006531047.1  ATP-binding cassette sub-family C member 12 isoform X1

      See identical proteins and their annotated locations for XP_006531047.1

      UniProtKB/Swiss-Prot
      B2RRF4, Q80WJ2, Q80WJ3, Q80WJ6, Q8C0P3
      Related
      ENSMUSP00000122402.2, ENSMUST00000131423.8
      Conserved Domains (1) summary
      TIGR00957
      Location:43 → 1366
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    2. XM_036154037.1 → XP_036009930.1  ATP-binding cassette sub-family C member 12 isoform X4

      Conserved Domains (1) summary
      PLN03130
      Location:6 → 827
      PLN03130; ABC transporter C family member; Provisional

    3. XM_006530985.5 → XP_006531048.1  ATP-binding cassette sub-family C member 12 isoform X2

      Conserved Domains (1) summary
      TIGR00957
      Location:1 → 983
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    4. XM_006530986.3 → XP_006531049.1  ATP-binding cassette sub-family C member 12 isoform X3

      Conserved Domains (1) summary
      TIGR00957
      Location:53 → 931
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    RNA

    1. XR_003947278.1 RNA Sequence

    2. XR_003947279.1 RNA Sequence

      Related
      ENSMUST00000156610.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WJ6.1 GenPept UniProtKB/Swiss-Prot:Q80WJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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