Ucp2 uncoupling protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ucp2provided by RGD
Official Full Name: uncoupling protein 2provided by RGD
Primary source: RGD:3932
See related: Ensembl:ENSRNOG00000017854 AllianceGenome:RGD:3932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxidative phosphorylation uncoupler activity. Involved in several processes, including cellular response to glucose stimulus; liver regeneration; and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Used to study hypertension; non-alcoholic fatty liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; fatty liver disease (multiple); hypothyroidism; obstructive jaundice; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 922.5), Heart (RPKM 460.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (164251373..164257742)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (154839242..154845612)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (165506375..165512744)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury.
Title: UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury.
GPER activation attenuates cardiac dysfunction by upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats.
Title: GPER activation attenuates cardiac dysfunction by upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats.
UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia.
Title: UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia.
An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation.
Title: An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation.
Hypoxia preconditioning improves structure and function of astrocytes mitochondria via PGC-1alpha/HIF signal.
Title: Hypoxia preconditioning improves structure and function of astrocytes mitochondria via PGC-1α/HIF signal.
Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models.
Title: Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models.
Alterations in Glucose Metabolism During the Transition to Heart Failure: The Contribution of UCP-2.
Title: Alterations in Glucose Metabolism During the Transition to Heart Failure: The Contribution of UCP-2.
Mitochondrial bioenergetics, uncoupling protein-2 activity, and reactive oxygen species production in the small intestine of a TNBS-induced colitis rat model.
Title: Mitochondrial bioenergetics, uncoupling protein-2 activity, and reactive oxygen species production in the small intestine of a TNBS-induced colitis rat model.
[Uncoupling protein 2 overexpression alleviates sepsis-induced myocardial injury via inhibiting reactive oxygen species production and inflammation].
Title: [Uncoupling protein 2 overexpression alleviates sepsis-induced myocardial injury via inhibiting reactive oxygen species production and inflammation].
UCP2 protect the heart from myocardial ischemia/reperfusion injury via induction of mitochondrial autophagy.
Title: UCP2 protect the heart from myocardial ischemia/reperfusion injury via induction of mitochondrial autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (101)

General gene information

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Markers

PMC297000P1 (e-PCR)
- UniSTS:272452

D1Wox38 (e-PCR)
- UniSTS:517777

RH94758 (e-PCR)
- UniSTS:120005

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables malate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables malate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxaloacetate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxaloacetate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidative phosphorylation uncoupler activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate ion uniporter activity	ISO Inferred from Sequence Orthology more info
enables phosphate ion uniporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables secondary active sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active sulfate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in C4-dicarboxylate transport	ISO Inferred from Sequence Orthology more info
involved_in C4-dicarboxylate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glutamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in long-chain fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in malate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in oxaloacetate(2-) transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to superoxide	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dicarboxylate carrier SLC25A8

Names: UCP 2; Uncoupling protein 2, mitochondrial; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein 2 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.