ZDHHC7 zinc finger DHHC-type palmitoyltransferase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZDHHC7provided by HGNC
Official Full Name: zinc finger DHHC-type palmitoyltransferase 7provided by HGNC
Primary source: HGNC:HGNC:18459
See related: Ensembl:ENSG00000153786 MIM:614604; AllianceGenome:HGNC:18459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DHHC7; SERZ1; SERZ-B; ZNF370
Summary: Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; polarized epithelial cell differentiation; and regulation of signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bone marrow (RPKM 20.6), lung (RPKM 20.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q24.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (84974175..85027631, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (91040795..91094281, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (85007781..85045141, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
Title: Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
demonstrated the importance of Zdhhc7 for assembling proper brain structure, function, and behavior on a system level in mice in a sex-related manner
Title: Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner.
identified DHHC7 as a JAM-C palmitoylating enzyme
Title: S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.
The ZDHHC7-mediated SCRIB palmitoylation is critical for SCRIB membrane targeting, cell polarity and tumor suppression, providing new mechanistic insights of how dynamic protein palmitoylation regulates cell polarity and tumorigenesis.
Title: ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.
DHHC7-mediated palmitoylation of Fas allows a proper Fas expression level by preventing its degradation through the lysosomes.
Title: Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.
the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function
Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	TAS Traceable Author Statement more info
enables protein-cysteine S-stearoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose import in response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-L-cysteine S-palmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-L-cysteine S-palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-L-cysteine S-palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarized epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progesterone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Fas signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to cell-cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid hormone mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC7

Names: DHHC-7; Sertoli cell gene with zinc finger domain-I(2); Sertoli cell gene with zinc finger domain-beta; acyltransferase ZDHHC7; zinc finger DHHC domain-containing protein 7; zinc finger DHHC-type containing 7; zinc finger protein 370; zinc finger, DHHC domain containing 7

NP_001139020.1

EC 2.3.1.225

NP_060210.2

EC 2.3.1.225

XP_011521524.1

EC 2.3.1.225

XP_024306111.1

EC 2.3.1.225

XP_047290306.1

EC 2.3.1.225

XP_047290307.1

EC 2.3.1.225

XP_047290308.1

EC 2.3.1.225

XP_047290309.1

EC 2.3.1.225

XP_047290310.1

EC 2.3.1.225

XP_047290311.1

EC 2.3.1.225

XP_047290312.1

EC 2.3.1.225

XP_047290313.1

EC 2.3.1.225

XP_047290314.1

EC 2.3.1.225

XP_054169420.1

EC 2.3.1.225

XP_054169421.1

EC 2.3.1.225

XP_054169422.1

EC 2.3.1.225

XP_054169423.1

EC 2.3.1.225

XP_054169424.1

EC 2.3.1.225

XP_054169425.1

EC 2.3.1.225

XP_054169426.1

EC 2.3.1.225

XP_054169427.1

EC 2.3.1.225

XP_054169428.1

EC 2.3.1.225

XP_054169429.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145548.2 → NP_001139020.1 palmitoyltransferase ZDHHC7 isoform 1

See identical proteins and their annotated locations for NP_001139020.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC092341, AW235073, BC018772, DA507340

Consensus CDS

CCDS45538.1

UniProtKB/Swiss-Prot

Q9NXF8

Related

ENSP00000456782.1, ENST00000564466.5

Conserved Domains (1) summary

pfam01529
Location:168 → 295

zf-DHHC; DHHC palmitoyltransferase
NM_017740.3 → NP_060210.2 palmitoyltransferase ZDHHC7 isoform 2

See identical proteins and their annotated locations for NP_060210.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a coding exon but maintains the reading frame compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC092341, AK000286, AW235073, CN427219, DA507340

Consensus CDS

CCDS10950.1

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

Related

ENSP00000315604.5, ENST00000313732.9

Conserved Domains (1) summary

pfam01529
Location:131 → 258

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

84974175..85027631 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047434355.1 → XP_047290311.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_047434352.1 → XP_047290308.1 palmitoyltransferase ZDHHC7 isoform X1
XM_047434353.1 → XP_047290309.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_047434350.1 → XP_047290306.1 palmitoyltransferase ZDHHC7 isoform X1
XM_047434356.1 → XP_047290312.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_047434354.1 → XP_047290310.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_047434351.1 → XP_047290307.1 palmitoyltransferase ZDHHC7 isoform X1
XM_024450343.2 → XP_024306111.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

Conserved Domains (1) summary

pfam01529
Location:131 → 258

DHHC; DHHC palmitoyltransferase
XM_047434358.1 → XP_047290314.1 palmitoyltransferase ZDHHC7 isoform X4
XM_047434357.1 → XP_047290313.1 palmitoyltransferase ZDHHC7 isoform X3
XM_011523222.3 → XP_011521524.1 palmitoyltransferase ZDHHC7 isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

91040795..91094281 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054313449.1 → XP_054169424.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_054313447.1 → XP_054169422.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_054313445.1 → XP_054169420.1 palmitoyltransferase ZDHHC7 isoform X1
XM_054313450.1 → XP_054169425.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_054313446.1 → XP_054169421.1 palmitoyltransferase ZDHHC7 isoform X1
XM_054313448.1 → XP_054169423.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_054313451.1 → XP_054169426.1 palmitoyltransferase ZDHHC7 isoform X2

UniProtKB/Swiss-Prot

D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
XM_054313453.1 → XP_054169428.1 palmitoyltransferase ZDHHC7 isoform X4
XM_054313454.1 → XP_054169429.1 palmitoyltransferase ZDHHC7 isoform X4
XM_054313452.1 → XP_054169427.1 palmitoyltransferase ZDHHC7 isoform X3