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    Pex14 Peroxin 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40294, updated on 10-May-2024

    Summary

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    Official Symbol
    Pex14provided by FlyBase
    Official Full Name
    Peroxin 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0037020
    Locus tag
    Dmel_CG4289
    See related
    AllianceGenome:FB:FBgn0037020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4289; DmelPex14; Dmel\CG4289; PEX14
    Summary
    Predicted to enable signaling receptor binding activity. Involved in peroxisome organization. Located in peroxisome. Is expressed in adult head; embryonic cortex; mesoderm; organism; and yolk. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 13A. Orthologous to human PEX14 (peroxisomal biogenesis factor 14). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Pex14 in Genome Data Viewer
    Location:
    77E6-77E6; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20778799..20780378)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20771899..20773478)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pitslre Neighboring gene Peroxin 16 Neighboring gene Phosphorylated CTD-interacting factor 1 Neighboring gene antisense RNA:CR46484 Neighboring gene uncharacterized protein Neighboring gene Six4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Peroxin 7 during Drosophila embryonic development. Pridie C, et al. Genome, 2021 Feb. PMID 32191843
    2. Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster. Shrestha S, et al. J Comput Biol, 2017 Dec. PMID 29035581, Free PMC Article
    3. Recruitment of Peroxin 14 to lipid droplets affects lipid storage in Drosophila. Ueda K, et al. J Cell Sci, 2022 Apr 1. PMID 35274690
    4. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Chen H, et al. Hum Mol Genet, 2010 Feb 1. PMID 19933170
    5. A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. Mast FD, et al. Dis Model Mech, 2011 Sep. PMID 21669930, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix, docking IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of peroxisomal importomer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxin 14
    Names
    CG4289-PA
    Pex14-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20778799..20780378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140996.4 → NP_649253.1  peroxin 14 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPB8
      Related
      FBpp0077909
      Conserved Domains (1) summary
      pfam04695
      Location:34 → 145
      Pex14_N; Peroxisomal membrane anchor protein (Pex14p) conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPB8 Q9VPB8

    Gene LinkOut

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