STK31 serine/threonine kinase 31 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK31provided by HGNC
Official Full Name: serine/threonine kinase 31provided by HGNC
Primary source: HGNC:HGNC:11407
See related: Ensembl:ENSG00000196335 MIM:605790; AllianceGenome:HGNC:11407
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TDRD8; SGK396
Summary: This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward testis (RPKM 35.6) See more
Orthologs: mouse all
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Genomic context

Location:: 7p15.3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (23710082..23832513)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (23849359..23971746)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (23749838..23872132)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer.
Title: Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer.
STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model.
Title: STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model.
Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival.
Title: Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival.
STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/betacatenin pathway and feedback regulation by cmyc.
Title: STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/β‑catenin pathway and feedback regulation by c‑myc.
FBLN1 and STK31 can be possible screening and differentiating biomarkers of colorectal cancer
Title: Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their ability to noninvasively differentiate colorectal cancer from benign polyps.
Relative STK31 expression level was significantly higher in patients with lymph node metastasis. STK31 expression levels in primary tumorous tissues of metastatic patients were significantly higher than in ANCTs and in lymph nodes samples, both at the RNA level and the protein level.
Title: STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.
Study demonstrates that, except the testes, STK31 is not expressed in normal tissues but aberrantly expressed in pancreatic cancer (PC) tissues, indicating that STK31 is a cancer-testis (CT) gene in PC. STK31 is reactivated by demethylation and, significantly higher in relapsed patients, or patients with advanced pathologic stage or poorer prognosis, suggesting that STK31 might be of potential clinical value.
Title: The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer.
The human papillomavirus type 16 oncogene E7 may affect STK31 expression through a DNA methylation-mediated mechanism.
Title: Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer.
the aberrant expression of STK31 contributes to tumorigenicity in somatic cancer cells
Title: STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells.
High STK31 expression is associated with colon cancer.
Title: STK31 maintains the undifferentiated state of colon cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G17197 (e-PCR)
- UniSTS:26720

G65768 (e-PCR)
- UniSTS:225911

D7S673 (e-PCR)
- UniSTS:17822

D7S673 (e-PCR)
- UniSTS:54457

D7S673 (e-PCR)
- UniSTS:31703

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase 31

Names: serine/threonine-protein kinase NYD-SPK; sugen kinase 396; testis tissue sperm-binding protein Li 78m; tudor domain containing 8

NP_001247433.1

EC 2.7.11.1

NP_001247434.1

EC 2.7.11.1

NP_113602.2

EC 2.7.11.1

NP_116562.2

EC 2.7.11.1

XP_006715821.1

EC 2.7.11.1

XP_011513751.2

EC 2.7.11.1

XP_011513752.1

EC 2.7.11.1

XP_011513754.2

EC 2.7.11.1

XP_054214627.1

EC 2.7.11.1

XP_054214628.1

EC 2.7.11.1

XP_054214629.1

EC 2.7.11.1

XP_054214630.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001260504.2 → NP_001247433.1 serine/threonine-protein kinase 31 isoform b

See identical proteins and their annotated locations for NP_001247433.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.

Source sequence(s)

AA315045, AC003087, AC008176, AF332194, AK131214, DA533364

Consensus CDS

CCDS43556.1

UniProtKB/TrEMBL

A0A140VKG1, A4D160

Related

ENSP00000346660.3, ENST00000354639.7

Conserved Domains (2) summary

cd20430
Location:38 → 112

Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins

cl21453
Location:805 → 945

PKc_like; Protein Kinases, catalytic domain
NM_001260505.2 → NP_001247434.1 serine/threonine-protein kinase 31 isoform c

See identical proteins and their annotated locations for NP_001247434.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AC003087, AC008176, AK302689

Consensus CDS

CCDS59049.1

UniProtKB/TrEMBL

A4D159

Related

ENSP00000411852.2, ENST00000433467.6

Conserved Domains (3) summary

cd04508
Location:89 → 129

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

pfam00567
Location:29 → 147

TUDOR; Tudor domain

cl21453
Location:802 → 986

PKc_like; Protein Kinases, catalytic domain
NM_031414.5 → NP_113602.2 serine/threonine-protein kinase 31 isoform a

See identical proteins and their annotated locations for NP_113602.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC003087, BC059374, DB065148

Consensus CDS

CCDS5386.1

UniProtKB/Swiss-Prot

B4DZ06, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8, Q9BXU1

UniProtKB/TrEMBL

A4D159

Related

ENSP00000348132.3, ENST00000355870.8

Conserved Domains (3) summary

cd04508
Location:89 → 129

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

pfam00567
Location:29 → 147

TUDOR; Tudor domain

cl21453
Location:802 → 921

PKc_like; Protein Kinases, catalytic domain
NM_032944.4 → NP_116562.2 serine/threonine-protein kinase 31 isoform b

See identical proteins and their annotated locations for NP_116562.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice-site in the 5' end that results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC003087, AC008176, BC059374, DB095141

Consensus CDS

CCDS43556.1

UniProtKB/TrEMBL

A0A140VKG1, A4D160

Conserved Domains (2) summary

cd20430
Location:38 → 112

Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins

cl21453
Location:805 → 945

PKc_like; Protein Kinases, catalytic domain

RNA

NR_048542.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA315045, AC003087, AC008176, AK131214, BC033018, DB089624

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

23710082..23832513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515452.4 → XP_011513754.2 serine/threonine-protein kinase 31 isoform X3

UniProtKB/TrEMBL

A4D160
XM_011515449.4 → XP_011513751.2 serine/threonine-protein kinase 31 isoform X1

UniProtKB/TrEMBL

A4D160

Related

ENSP00000519677.1, ENST00000528479.6
XM_006715758.5 → XP_006715821.1 serine/threonine-protein kinase 31 isoform X4

UniProtKB/TrEMBL

A4D159

Conserved Domains (3) summary

cd04508
Location:89 → 129

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

pfam00567
Location:29 → 147

TUDOR; Tudor domain

cl21453
Location:624 → 743

PKc_like; Protein Kinases, catalytic domain
XM_011515450.2 → XP_011513752.1 serine/threonine-protein kinase 31 isoform X2

See identical proteins and their annotated locations for XP_011513752.1

UniProtKB/TrEMBL

A0A140VKG1, A4D160

Conserved Domains (2) summary

cd20430
Location:38 → 112

Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins

cl21453
Location:805 → 945

PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

23849359..23971746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358654.1 → XP_054214629.1 serine/threonine-protein kinase 31 isoform X3
XM_054358652.1 → XP_054214627.1 serine/threonine-protein kinase 31 isoform X1
XM_054358655.1 → XP_054214630.1 serine/threonine-protein kinase 31 isoform X4
XM_054358653.1 → XP_054214628.1 serine/threonine-protein kinase 31 isoform X2

UniProtKB/TrEMBL

A0A140VKG1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001122833.1: Suppressed sequence

Description

NM_001122833.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.