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    tai taiman [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34242, updated on 10-May-2024

    Summary

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    Official Symbol
    taiprovided by FlyBase
    Official Full Name
    taimanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041092
    Locus tag
    Dmel_CG13109
    See related
    AllianceGenome:FB:FBgn0041092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    58/2; bs13g05.y1; CG13109; CG18494; DAIB1; Dmel\CG13109; DmTai; DmTaiman; EP(2)2630; l(2)01351; l(2)k05802; l(2)k05809; NEST:bs13g05; Tai; TAI; Taiman
    Summary
    Enables nuclear receptor binding activity; nuclear receptor coactivator activity; and transcription coactivator binding activity. Involved in several processes, including border follicle cell migration; germ-line stem-cell niche homeostasis; and positive regulation of border follicle cell migration. Located in nucleus. Is expressed in several structures, including gonad and olfactory receptor neurons. Human ortholog(s) of this gene implicated in acute myeloid leukemia and obesity. Orthologous to human NCOA1 (nuclear receptor coactivator 1); NCOA2 (nuclear receptor coactivator 2); and NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See tai in Genome Data Viewer
    Location:
    30A2-30A6; 2-35 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9166778..9250211)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9166778..9250211)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Threonine-AGT 1-1 Neighboring gene pseudo Neighboring gene australin Neighboring gene borealin-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Society for Developmental Biology meeting. A mile-high view of development. Vogel G. Science, 2000 Jun 23. PMID 10896577
    2. Pruning deficits of the developing Drosophila mushroom body result in mild impairment in associative odour learning and cause hyperactivity. Poppinga H, et al. Open Biol, 2022 Sep. PMID 36128716, Free PMC Article
    3. Detection of juvenile hormone agonists by a new reporter gene assay using yeast expressing Drosophila methoprene-tolerant. Ito-Harashima S, et al. FEBS Open Bio, 2021 Oct. PMID 34407562, Free PMC Article
    4. Virtual screening identifies a novel piperazine-based insect juvenile hormone agonist. Yokoi T, et al. J Pestic Sci, 2021 Feb 20. PMID 33746548, Free PMC Article
    5. Transcription-inducing activity of natural and synthetic juvenile hormone agonists through the Drosophila Methoprene-tolerant protein. Yokoi T, et al. Pest Manag Sci, 2020 Jul. PMID 32003111

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tai expression transforms sessile pupal wing cells into an invasive mass that penetrates the adjacent thorax during a period of high 20-hydroxyecdysone.
      Title: The Taiman Transcriptional Coactivator Engages Toll Signals to Promote Apoptosis and Intertissue Invasion in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 9194175-9194262 mobile_element_type = transposon:INE-1{}5737

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    taiman
    Names
    CG13109-PC
    CG13109-PD
    CG13109-PE
    CG13109-PF
    CG13109-PG
    CG13109-PH
    drosophila amplified in breast cancer-1
    tai-PC
    tai-PD
    tai-PE
    tai-PF
    tai-PG
    tai-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9166778..9250211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259020.2 → NP_001245949.1  taiman, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND53, Q9GS19
      Conserved Domains (3) summary
      smart00091
      Location:377 → 442
      PAS; PAS domain
      cd00083
      Location:235 → 286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam14598
      Location:591 → 711
      PAS_11; PAS domain

    2. NM_078797.4 → NP_523521.3  taiman, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523521.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GS19, Q9VLD9
      Conserved Domains (3) summary
      smart00091
      Location:377 → 442
      PAS; PAS domain
      cd00083
      Location:235 → 286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam14598
      Location:591 → 711
      PAS_11; PAS domain

    3. NM_001273351.1 → NP_001260280.1  taiman, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260280.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRG5, Q9GS19
      Conserved Domains (3) summary
      smart00091
      Location:377 → 442
      PAS; PAS domain
      cd00083
      Location:235 → 286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam14598
      Location:591 → 711
      PAS_11; PAS domain

    4. NM_001201819.2 → NP_001188748.1  taiman, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRG5, Q9GS19
      Conserved Domains (3) summary
      smart00091
      Location:377 → 442
      PAS; PAS domain
      cd00083
      Location:235 → 286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam14598
      Location:591 → 711
      PAS_11; PAS domain

    5. NM_001201818.1 → NP_001188747.1  taiman, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRJ8, Q9GS19
      Conserved Domains (3) summary
      smart00091
      Location:377 → 442
      PAS; PAS domain
      cd00083
      Location:235 → 286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam14598
      Location:591 → 711
      PAS_11; PAS domain

    6. NM_001201817.1 → NP_001188746.1  taiman, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GS19, Q9VLD9
      Conserved Domains (3) summary
      smart00091
      Location:377 → 442
      PAS; PAS domain
      cd00083
      Location:235 → 286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam14598
      Location:591 → 711
      PAS_11; PAS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRG5 M9MRG5
    M9MRJ8 M9MRJ8
    M9ND53 M9ND53
    Q9GS19 Q9GS19
    Q9VLD9 Q9VLD9

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