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    CaMKII Calcium/calmodulin-dependent protein kinase II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43828, updated on 10-May-2024

    Summary

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    Official Symbol
    CaMKIIprovided by FlyBase
    Official Full Name
    Calcium/calmodulin-dependent protein kinase IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264607
    Locus tag
    Dmel_CG18069
    See related
    AllianceGenome:FB:FBgn0264607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ca2+/calmodulin-dependent protein kinase II; Calcium/calmodulin-dependent protein kinase; calcium/calmodulin-dependent protein kinase II; Cam; CaM; CaM II; CaM KII; CaM kinase; camk II; CaMK II; CamK-II; CaMK-II; camkii; camkII; camKII; Camkii; CamKII; CaMKii; CAMKII; CamKIIalpha; CAMKIIalpha; CAMKIId; CDPK1; CG18069; dCaMKII; dCAMKII; DCK; Dmel\CG18069; l(4)102EFb; l(4)16; l(4)ar
    Summary
    Enables calmodulin-dependent protein kinase activity. Involved in several processes, including long-term memory; peptidyl-threonine autophosphorylation; and regulation of filopodium assembly. Acts upstream of with a positive effect on positive regulation of dopaminergic synaptic transmission. Located in several cellular components, including dendrite; postsynaptic membrane; and presynaptic active zone. Is expressed in several structures, including A1-7 ventral longitudinal muscle cell; anterior endoderm; central nervous system; extended germ band embryo; and eye. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53; autosomal dominant mental retardation 54; autosomal dominant non-syndromic intellectual disability; and autosomal recessive non-syndromic intellectual disability. Orthologous to several human genes including CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CaMKII in Genome Data Viewer
    Location:
    102F6-102F7; 4-0 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1035288..1053703, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1055914..1074329, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44031 Neighboring gene ATP synthase, beta subunit Neighboring gene uncharacterized protein Neighboring gene Mitochondrial inner membrane protein MPV17 Neighboring gene Zyxin Neighboring gene apolipophorin Neighboring gene Activin-beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pairing-Dependent Plasticity in a Dissected Fly Brain Is Input-Specific and Requires Synaptic CaMKII Enrichment and Nighttime Sleep. Adel M, et al. J Neurosci, 2022 May 25. PMID 35474278, Free PMC Article
    2. Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. Oka M, et al. J Biochem, 2017 Nov 1. PMID 28992057, Free PMC Article
    3. Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster. Santalla M, et al. PLoS One, 2014. PMID 25003749, Free PMC Article
    4. [Imaging monitoring method of CaMKII activity by immunohistochemical analysis in schizophrenic model rats]. Yabuki Y, et al. Yakugaku Zasshi, 2013. PMID 23649390
    5. Constitutive activation of Ca2+/calmodulin-dependent protein kinase II during development impairs central cholinergic transmission in a circuit underlying escape behavior in Drosophila. Kadas D, et al. J Neurosci, 2012 Jan 4. PMID 22219280, Free PMC Article

    See all (267) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2).
      Title: TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2).
    2. CaMKII may time a wide variety of behavioral and cognitive processes.
      Title: CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State.
    3. we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of mushroom body neurons for later consolidation. Consolidation involves the subsequent recruitment of Orb2B and the activity-dependent synthesis of CaMKII
      Title: Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila.
    4. It is NMDA receptor downstream kinase and essential for memory and learning acquisition.(review)
      Title: [Imaging monitoring method of CaMKII activity by immunohistochemical analysis in schizophrenic model rats].
    5. these data support a model in which CaMKII-mediated synapsin phosphorylation in local circuit interneurons induces synaptic vesicle mobilization and thereby presynaptic facilitation of GABA release that underlies olfactory short-term habituation.
      Title: Synapsin function in GABA-ergic interneurons is required for short-term olfactory habituation.
    6. Regulated CaMKII autophosphorylation appears essential in central synapse development, and particular cholinergic synapses are affected differentially, although they operate via the same nicotinic receptor.
      Title: Constitutive activation of Ca2+/calmodulin-dependent protein kinase II during development impairs central cholinergic transmission in a circuit underlying escape behavior in Drosophila.
    7. These results suggest that presynaptic CaMKII activation depends on autophosphorylation and global Ca(2+) in the terminal, while translocation to AZs requires Ca(2+) microdomains generated by IP3Rs.
      Title: Differential control of presynaptic CaMKII activation and translocation to active zones.
    8. This study indicated a role for patterned electrical activity and presynaptic calcium signaling, acting through CaMKII, in modulating a retrograde signal during the refinement of synaptic connections.
      Title: Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement.
    9. We found that postsynaptic CaMKII regulates the localization of GluRIIA and GluRIIB, we hypothesize that postsynaptic CaMKII activity monitors the calcium influx through GluRIIA and regulate the amount of synaptic GluRIIA during larval stages
      Title: Subunit-specific and homeostatic regulation of glutamate receptor localization by CaMKII in Drosophila neuromuscular junctions.
    10. CaMKII is involved in the negative regulation of the visual response affecting light adaptation, possibly by catalyzing phosphorylation of Arr2
      Title: Role of Ca2+/calmodulin-dependent protein kinase II in Drosophila photoreceptors.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c1042714-1042174 mobile_element_type = transposon:INE-1{}3385
    • Loc: c1042985-1042789 mobile_element_type = transposon:INE-1{}3388
    • Loc: c1044309-1044162 mobile_element_type = transposon:INE-1{}3391
    • Loc: c1047067-1046766 mobile_element_type = transposon:INE-1{}3406
    • Loc: c1050149-1049729 mobile_element_type = transposon:INE-1{}3408
    • Loc: c1051956-1051622 mobile_element_type = transposon:INE-1{}3409

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in courtship behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in learning or memory NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidyl-threonine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_positive_effect positive regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ovulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calcium/calmodulin-dependent protein kinase II
    Names
    CG18069-PA
    CG18069-PB
    CG18069-PC
    CG18069-PD
    CG18069-PE
    CG18069-PG
    CG18069-PH
    CG18069-PI
    CG18069-PJ
    CG18069-PK
    CG18069-PL
    CG18069-PM
    Ca2+ calmodulin-dependent kinase II
    Ca2+/calmodulin-dependent protein kinase II
    CaM kinase
    CaM kinase II
    CaM-kinase-II
    CaMKII-PA
    CaMKII-PB
    CaMKII-PC
    CaMKII-PD
    CaMKII-PE
    CaMKII-PG
    CaMKII-PH
    CaMKII-PI
    CaMKII-PJ
    CaMKII-PK
    CaMKII-PL
    CaMKII-PM
    Ca[2+]-calmodulin-dependent protein kinase II
    Ca[2+]/calmodulin-dependent protein kinase II
    Calcium/calmodulin-dependent protein kinase
    Calcium/calmodulin-dependent protein kinase ii
    calcium/ calmodulin-dependent protein kinase II
    calcium/calmodulin-dependent protein kinase type II
    calmodulin kinase II
    calmodulin-dependent kinase
    calmodulin-dependent protein kinase II
    lethal (4) 102EFb
    NP_001014696.1
    NP_001162831.1
    NP_001162832.1
    NP_001162833.1
    NP_001259082.1
    NP_001259083.1
    NP_001259084.1
    NP_524635.3
    NP_726633.2
    NP_726634.1
    NP_726635.2
    NP_726636.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1035288..1053703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272153.1 → NP_001259082.1  Calcium/calmodulin-dependent protein kinase II, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259082.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MNA2
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:348 → 468
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    2. NM_079896.4 → NP_524635.3  Calcium/calmodulin-dependent protein kinase II, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524635.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V133
      Related
      FBpp0088281
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:349 → 476
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    3. NM_001272155.1 → NP_001259084.1  Calcium/calmodulin-dependent protein kinase II, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MLP2
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:370 → 490
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    4. NM_001272154.1 → NP_001259083.1  Calcium/calmodulin-dependent protein kinase II, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MLR4
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:388 → 508
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    5. NM_166813.3 → NP_726636.2  Calcium/calmodulin-dependent protein kinase II, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726636.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V134
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:368 → 495
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    6. NM_001014696.2 → NP_001014696.1  Calcium/calmodulin-dependent protein kinase II, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014696.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q00168
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:375 → 502
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    7. NM_166812.3 → NP_726635.2  Calcium/calmodulin-dependent protein kinase II, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726635.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q00168, Q59DP1, Q59DP2, Q9V495
      UniProtKB/TrEMBL
      D1YSG7
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:389 → 516
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    8. NM_166810.5 → NP_726633.2  Calcium/calmodulin-dependent protein kinase II, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726633.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V133
      Related
      FBpp0088282
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:349 → 476
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    9. NM_001169361.2 → NP_001162832.1  Calcium/calmodulin-dependent protein kinase II, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q00168, Q59DP1, Q59DP2, Q9V495
      UniProtKB/TrEMBL
      D1YSG7
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:389 → 516
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    10. NM_166811.2 → NP_726634.1  Calcium/calmodulin-dependent protein kinase II, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V134
      Related
      FBpp0088283
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:368 → 495
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    11. NM_001169362.2 → NP_001162833.1  Calcium/calmodulin-dependent protein kinase II, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1YSG8
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:390 → 517
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    12. NM_001169360.2 → NP_001162831.1  Calcium/calmodulin-dependent protein kinase II, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V133
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:349 → 476
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V133 A4V133
    A4V134 A4V134
    D1YSG7 D1YSG7
    D1YSG8 D1YSG8
    L0MLP2 L0MLP2
    L0MLR4 L0MLR4
    L0MNA2 L0MNA2
    Q00168.1 Q00168
    Q24045 Q24045

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