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    Tamm41 TAM41 mitochondrial translocator assembly and maintenance homolog [ Mus musculus (house mouse) ]

    Gene ID: 68971, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tamm41provided by MGI
    Official Full Name
    TAM41 mitochondrial translocator assembly and maintenance homologprovided by MGI
    Primary source
    MGI:MGI:1916221
    See related
    Ensembl:ENSMUSG00000030316 AllianceGenome:MGI:1916221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAM41; 1500001M20Rik
    Summary
    Predicted to enable phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process and cardiolipin biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Located in mitochondrion. Orthologous to human TAMM41 (TAM41 mitochondrial translocator assembly and maintenance homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 17.1), ovary adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tamm41 in Genome Data Viewer
    Location:
    6 E3; 6 53.14 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114981342..115014890, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115004381..115037929, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vestigial like family member 4 Neighboring gene predicted gene, 38876 Neighboring gene STARR-seq mESC enhancer starr_17074 Neighboring gene predicted gene, 52944 Neighboring gene STARR-seq mESC enhancer starr_17075 Neighboring gene STARR-positive B cell enhancer ABC_E6470 Neighboring gene predicted gene, 36190 Neighboring gene predicted gene, 17733

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidate cytidylyltransferase, mitochondrial
    Names
    CDP-DAG synthase
    CDP-diacylglycerol synthase
    MMP37-like protein, mitochondrial
    TAM41, mitochondrial translocator assembly and maintenance protein, homolog
    mitochondrial translocator assembly and maintenance protein 41 homolog
    NP_081170.1
    XP_006506615.1
    XP_006506616.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026894.1 → NP_081170.1  phosphatidate cytidylyltransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_081170.1

      Status: VALIDATED

      Source sequence(s)
      AK005100, BB857425, BE956902
      Consensus CDS
      CCDS20437.1
      UniProtKB/Swiss-Prot
      Q3TUH1
      UniProtKB/TrEMBL
      G5E881
      Related
      ENSMUSP00000032461.6, ENSMUST00000032461.12
      Conserved Domains (1) summary
      pfam09139
      Location:13 → 327
      Mmp37; Mitochondrial matrix Mmp37

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      114981342..115014890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506552.2 → XP_006506615.1  phosphatidate cytidylyltransferase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3TUH1
      Conserved Domains (1) summary
      pfam09139
      Location:13 → 277
      Mmp37; Mitochondrial matrix Mmp37

    2. XM_006506553.5 → XP_006506616.1  phosphatidate cytidylyltransferase, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam09139
      Location:3 → 185
      Mmp37; Mitochondrial matrix Mmp37

    RNA

    1. XR_377489.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TUH1.2 GenPept UniProtKB/Swiss-Prot:Q3TUH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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