COPS5 COP9 signalosome subunit 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: COPS5provided by HGNC
Official Full Name: COP9 signalosome subunit 5provided by HGNC
Primary source: HGNC:HGNC:2240
See related: Ensembl:ENSG00000121022 MIM:604850; AllianceGenome:HGNC:2240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CSN5; JAB1; SGN5; MOV-34
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 37.3), heart (RPKM 32.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q13.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (67043079..67062133, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (67469560..67488599, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (67955314..67974368, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.
Title: Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.
METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.
Title: METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.
Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.
Title: Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.
PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of beta-catenin and PD-L1.
Title: PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1.
PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data.
Title: PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data.
Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-kappaB/STAT3 and NF-kappaB/CSN5 signaling pathways.
Title: Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways.
CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.
Title: CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes.
Title: JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes.
Jab1/Cops5: a promising target for cancer diagnosis and therapy.
Title: Jab1/Cops5: a promising target for cancer diagnosis and therapy.
alpha5-nAChR contributes to epithelial-mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer.
Title: α5-nAChR contributes to epithelial-mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer.

Submit: New GeneRIF Correction See all GeneRIFs (130)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 5 (COPS5; CSN5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
capsid	gag	The interaction of HIV-1 CA with human cellular COP9 signalosome subunit 5 protein (COPS5) is identified by yeast two-hybrid screen	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:314409 (e-PCR)
- UniSTS:54038

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

D11S3732 (e-PCR)
- UniSTS:152962

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables deNEDDylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deNEDDylase activity	TAS Traceable Author Statement more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables macrophage migration inhibitory factor binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal-dependent deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables translation initiation factor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in exosomal secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in post-translational protein modification	TAS Traceable Author Statement more info
involved_in protein deneddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deneddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deneddylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	NAS Non-traceable Author Statement more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein neddylation	NAS Non-traceable Author Statement more info	PubMed
involved_in translation	TAS Traceable Author Statement more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of COP9 signalosome	IPI Inferred from Physical Interaction more info	PubMed
part_of COP9 signalosome	ISS Inferred from Sequence or Structural Similarity more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic translation initiation factor 3 complex	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: COP9 signalosome complex subunit 5

Names: 38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5; jun activation domain-binding protein 1; signalosome subunit 5; testis secretory sperm-binding protein Li 231m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006837.3 → NP_006828.2 COP9 signalosome complex subunit 5

See identical proteins and their annotated locations for NP_006828.2

Status: REVIEWED

Source sequence(s)

BC001187, BI752436

Consensus CDS

CCDS6198.1

UniProtKB/Swiss-Prot

O15386, Q6AW95, Q86WQ4, Q92905, Q9BQ17

UniProtKB/TrEMBL

A0A024R7W9

Related

ENSP00000350512.4, ENST00000357849.9

Conserved Domains (1) summary

cd08069
Location:44 → 314

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5