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    Tmem181a transmembrane protein 181A [ Mus musculus (house mouse) ]

    Gene ID: 77106, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tmem181aprovided by MGI
    Official Full Name
    transmembrane protein 181Aprovided by MGI
    Primary source
    MGI:MGI:1924356
    See related
    Ensembl:ENSMUSG00000038141 AllianceGenome:MGI:1924356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr178; Tmem181; mKIAA1423; 5930418K15Rik
    Summary
    Predicted to enable toxic substance binding activity. Is expressed in several structures, including cardiovascular system; central nervous system; gut; reproductive system; and trachea. Orthologous to human TMEM181 (transmembrane protein 181). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 47.1), frontal lobe adult (RPKM 44.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem181a in Genome Data Viewer
    Location:
    17 A1; 17 3.85 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6307001..6358589)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6256726..6308314)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TUB like protein 4 Neighboring gene fibrillarin pseudogene Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_41716 Neighboring gene STARR-seq mESC enhancer starr_41717 Neighboring gene STARR-positive B cell enhancer mm9_chr17:6314045-6314346 Neighboring gene STARR-seq mESC enhancer starr_41718 Neighboring gene dynein light chain Tctex-type 1A Neighboring gene STARR-seq mESC enhancer starr_41719 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 2, pseudogene 1 Neighboring gene tubby like protein 4 pseudogene Neighboring gene fibrillarin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC182481

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables toxic substance binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 181

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033178.3 → NP_001028350.1  transmembrane protein 181 isoform 1

      See identical proteins and their annotated locations for NP_001028350.1

      Status: VALIDATED

      Source sequence(s)
      AC183097, AW825806, BE862876, BQ832419, CD539539, CF747635, CJ168748
      Consensus CDS
      CCDS37425.1
      UniProtKB/TrEMBL
      B2RVR2, Q3U3W2
      Related
      ENSMUSP00000086333.5, ENSMUST00000088940.6
      Conserved Domains (1) summary
      pfam06664
      Location:127 → 422
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    2. NM_001357884.1 → NP_001344813.1  transmembrane protein 181 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092481, AC183097, CF747635
      Consensus CDS
      CCDS88983.1
      UniProtKB/TrEMBL
      A0A338P7C9, B2RVR2
      Related
      ENSMUSP00000156382.2, ENSMUST00000232383.2
      Conserved Domains (1) summary
      pfam06664
      Location:168 → 463
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      6307001..6358589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250141.1 → XP_030106001.1  transmembrane protein 181 isoform X1

      UniProtKB/TrEMBL
      B2RVR2
      Conserved Domains (1) summary
      pfam06664
      Location:168 → 463
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    2. XM_030250142.1 → XP_030106002.1  transmembrane protein 181 isoform X2

      UniProtKB/TrEMBL
      B2RVR2
      Conserved Domains (1) summary
      pfam06664
      Location:168 → 463
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    3. XM_030250144.2 → XP_030106004.1  transmembrane protein 181 isoform X3

      Conserved Domains (1) summary
      pfam06664
      Location:1 → 263
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    RNA

    1. XR_876333.2 RNA Sequence

    2. XR_003952212.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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