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    Adad1 adenosine deaminase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 21744, updated on 12-May-2024

    Summary

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    Official Symbol
    Adad1provided by MGI
    Official Full Name
    adenosine deaminase domain containing 1provided by MGI
    Primary source
    MGI:MGI:103258
    See related
    Ensembl:ENSMUSG00000027719 AllianceGenome:MGI:103258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tenr
    Summary
    Enables RNA binding activity. Acts upstream of or within spermatid development. Located in nucleus. Is expressed in brain; genitourinary system; and inner ear. Orthologous to human ADAD1 (adenosine deaminase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 32.6) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 B; 3 18.3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (37117805..37165661)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (37063656..37111512)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, mitochondrial 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07428 Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene STARR-seq mESC enhancer starr_07429 Neighboring gene STARR-seq mESC enhancer starr_07431 Neighboring gene STARR-seq mESC enhancer starr_07432 Neighboring gene zinc finger, CCHC domain containing 17 pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene 12584 Neighboring gene interleukin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Lu Y, et al. Andrology, 2023 May. PMID 36698249, Free PMC Article
    2. Disruption of murine Tenr results in teratospermia and male infertility. Connolly CM, et al. Dev Biol, 2005 Feb 1. PMID 15649457
    3. Crystal structure of TB-RBP, a novel RNA-binding and regulating protein. Pascal JM, et al. J Mol Biol, 2002 Jun 21. PMID 12079346
    4. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Lyons PA, et al. Genome Res, 2000 Apr. PMID 10779485, Free PMC Article
    5. Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse. Schumacher JM, et al. Biol Reprod, 1995 Jun. PMID 7543294

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAD1 is required for normal translation of nuclear pore and transport protein transcripts in spermatids of Mus musculusdagger.
      Title: ADAD1 is required for normal translation of nuclear pore and transport protein transcripts in spermatids of Mus musculus†.
    2. ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
      Title: ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
    3. Targeted mutation of the Tenr gene causes male sterility. Tenr mutant males have a reduced sperm count, and Tenr-/- sperm show a decrease in motility and an increase in malformed heads.
      Title: Disruption of murine Tenr results in teratospermia and male infertility.
    4. 2.65 A crystal structure of mouse TB-RBP
      Title: Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT acts_upstream_of_or_within regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase domain-containing protein 1
    Names
    adenosine deaminase domain containing 1 (testis specific)
    testis nuclear RNA binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009350.3 → NP_033376.2  adenosine deaminase domain-containing protein 1

      See identical proteins and their annotated locations for NP_033376.2

      Status: VALIDATED

      Source sequence(s)
      AL662823
      Consensus CDS
      CCDS17315.1
      UniProtKB/Swiss-Prot
      A2AAD7, A2AAD8, A2AAV1, Q08EL2, Q3V0N7, Q5SUE7, Q62309, Q9JLB6
      UniProtKB/TrEMBL
      F8WI80
      Related
      ENSMUSP00000115260.2, ENSMUST00000144629.8
      Conserved Domains (2) summary
      smart00358
      Location:139 → 204
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:246 → 618
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      37117805..37165661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SUE7.1 GenPept UniProtKB/Swiss-Prot:Q5SUE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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