Rab8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab8provided by FlyBase
Primary source: FLYBASE:FBgn0262518
Locus tag: Dmel_CG8287
See related: AllianceGenome:FB:FBgn0262518
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF49101; CG8287; Dm Rab8; dm-Rab8; Dmel\CG8287; DmRab8; DRab8; DRAB8; l(3)76BDu; O18338; Rab-r8; rab8
Summary: Predicted to enable GTPase activity. Involved in polarized secretion of basement membrane proteins in epithelium; protein localization to membrane; and regulation of synaptic assembly at neuromuscular junction. Located in several cellular components, including Golgi apparatus; neuronal cell body; and recycling endosome. Is expressed in several structures, including central nervous system; gut section; imaginal disc; mesoderm; and photoreceptor. Orthologous to human RAB8A (RAB8A, member RAS oncogene family) and RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 76D2-76D3; 3-46 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19867488..19871078, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19860588..19864178, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution.
Title: The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution.
Rab8 Promotes Mutant HTT Aggregation, Reduces Neurodegeneration, and Ameliorates Behavioural Alterations in a Drosophila Model of Huntington's Disease.
Title: Rab8 Promotes Mutant HTT Aggregation, Reduces Neurodegeneration, and Ameliorates Behavioural Alterations in a Drosophila Model of Huntington's Disease.
Strat is required to localize Rab8 at the TGN, and rab8 phenocopies strat We propose that Strat and Rab8 act at the exit of the Golgi apparatus to regulate the sorting and the polarized distribution of Notch, Delta and Spdo.
Title: Stratum recruits Rab8 at Golgi exit sites to regulate the basolateral sorting of Notch and Sanpodo.
Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
Title: Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
active Rab8 populations direct furrow ingression by guiding the targeted delivery of cytoplasmic membrane stores to the cell surface through interactions with the exocyst tethering complex
Title: Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster.
The data data uncover Rab8, POSH, and TAK1 as regulators of synaptic growth responses and point to recycling endosome as a key compartment for synaptic growth regulation during neurodegenerative processes.
Title: Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia.
Rab8 ameliorated alpha-synuclein-oligomer specific locomotor impairment and neuron loss in fruit flies
Title: α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in polarized secretion of basement membrane proteins in epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	HDA more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	HDA more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	HDA more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Rab8

Names: CG8287-PA; CG8287-PB; CG8287-PC; Rab-protein 8; Rab8-PA; Rab8-PB; Rab8-PC; l(3)76BDu

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19867488..19871078 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079448.4 → NP_524172.1 Rab8, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524172.1

Status: REVIEWED

UniProtKB/TrEMBL

D5AEN5, O18338

Related

FBpp0074690

Conserved Domains (1) summary

cd01867
Location:6 → 172

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)
NM_001259908.2 → NP_001246837.1 Rab8, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246837.1

Status: REVIEWED

UniProtKB/TrEMBL

D5AEN5, O18338

Conserved Domains (1) summary

cd01867
Location:6 → 172

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)
NM_001259907.1 → NP_001246836.1 Rab8, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246836.1

Status: REVIEWED

UniProtKB/TrEMBL

D5AEN5, M9NEE8

Conserved Domains (2) summary

smart00175
Location:7 → 137

RAB; Rab subfamily of small GTPases

cl21455
Location:7 → 137

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases