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    Papss PAPS synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40167, updated on 10-May-2024

    Summary

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    Official Symbol
    Papssprovided by FlyBase
    Official Full Name
    PAPS synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020389
    Locus tag
    Dmel_CG8363
    See related
    AllianceGenome:FB:FBgn0020389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8363; Dmel\CG8363; DmPAPSS; l(3)76BDn; paps; Paps; PAPS; papss; PAPSS
    Summary
    Predicted to enable adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Located in nucleoplasm. Is expressed in several structures, including adult head; embryonic epidermis; and foregut. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) and PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Papss in Genome Data Viewer
    Location:
    76D1-76D2; 3-46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19845293..19860925)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19838393..19854025)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene kohtalo Neighboring gene long non-coding RNA:CR45433 Neighboring gene Rab8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA sequence and expression pattern of the Drosophila melanogaster PAPS synthetase gene: a new salivary gland marker. Jullien D, et al. Mech Dev, 1997 Nov. PMID 9431815
    2. Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe. Zhang Z, et al. Development, 2009 Aug. PMID 19633171, Free PMC Article
    3. Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells. Besset S, et al. FASEB J, 2000 Feb. PMID 10657990
    4. Synthesis of the sulfate donor PAPS in either the Drosophila germline or somatic follicle cells can support embryonic dorsal-ventral axis formation. Zhu X, et al. Development, 2007 Apr. PMID 17344226
    5. Glycosyltransferases and transporters that contribute to proteoglycan synthesis in Drosophila: Identification and functional analyses using the heritable and inducible RNAi system. Nishihara S. Methods Enzymol, 2010. PMID 20816216

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There is the movement of PAPS between the germline and the follicle cells, which highlights a previously unappreciated mechanism of soma/germline cooperation affecting pattern formation.
      Title: Synthesis of the sulfate donor PAPS in either the Drosophila germline or somatic follicle cells can support embryonic dorsal-ventral axis formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    PAPS synthetase
    Names
    CG8363-PA
    CG8363-PB
    CG8363-PC
    CG8363-PD
    CG8363-PE
    CG8363-PF
    CG8363-PG
    CG8363-PH
    PAPs synthase
    Papss-PA
    Papss-PB
    Papss-PC
    Papss-PD
    Papss-PE
    Papss-PF
    Papss-PG
    Papss-PH
    paps synthetase
    NP_001036617.1
    NP_001262072.1
    NP_001262073.1
    NP_524171.2
    NP_730457.1
    NP_730458.1
    NP_730459.1
    NP_730460.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19845293..19860925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043152.2 → NP_001036617.1  PAPS synthetase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02638, Q7KUT8, Q9VW48
      Conserved Domains (3) summary
      cd00517
      Location:252 → 623
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:243 → 621
      sopT; ATP sulphurylase
      pfam01583
      Location:46 → 201
      APS_kinase; Adenylylsulphate kinase

    2. NM_168823.3 → NP_730459.1  PAPS synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730459.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02638, Q961A8, Q9VW48
      Related
      FBpp0074655
      Conserved Domains (3) summary
      cd00517
      Location:251 → 622
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:242 → 620
      sopT; ATP sulphurylase
      pfam01583
      Location:45 → 200
      APS_kinase; Adenylylsulphate kinase

    3. NM_001275143.1 → NP_001262072.1  PAPS synthetase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02638, Q961A8, Q9VW48
      Conserved Domains (3) summary
      cd00517
      Location:251 → 622
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:242 → 620
      sopT; ATP sulphurylase
      pfam01583
      Location:45 → 200
      APS_kinase; Adenylylsulphate kinase

    4. NM_168821.3 → NP_730457.1  PAPS synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02638, Q961A8, Q9VW48
      Related
      FBpp0074656
      Conserved Domains (3) summary
      cd00517
      Location:251 → 622
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:242 → 620
      sopT; ATP sulphurylase
      pfam01583
      Location:45 → 200
      APS_kinase; Adenylylsulphate kinase

    5. NM_168822.3 → NP_730458.1  PAPS synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02638, Q961A8, Q9VW48
      Related
      FBpp0074654
      Conserved Domains (3) summary
      cd00517
      Location:251 → 622
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:242 → 620
      sopT; ATP sulphurylase
      pfam01583
      Location:45 → 200
      APS_kinase; Adenylylsulphate kinase

    6. NM_001275144.1 → NP_001262073.1  PAPS synthetase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02638, Q7KUT8, Q9VW48
      Conserved Domains (3) summary
      cd00517
      Location:252 → 623
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:243 → 621
      sopT; ATP sulphurylase
      pfam01583
      Location:46 → 201
      APS_kinase; Adenylylsulphate kinase

    7. NM_168824.3 → NP_730460.1  PAPS synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP52, Q8IQV1
      Related
      FBpp0074657
      Conserved Domains (3) summary
      cd00517
      Location:279 → 650
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:270 → 648
      sopT; ATP sulphurylase
      pfam01583
      Location:73 → 228
      APS_kinase; Adenylylsulphate kinase

    8. NM_079447.4 → NP_524171.2  PAPS synthetase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524171.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02638, Q7KUT8, Q9VW48
      Related
      FBpp0074658
      Conserved Domains (3) summary
      cd00517
      Location:252 → 623
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:243 → 621
      sopT; ATP sulphurylase
      pfam01583
      Location:46 → 201
      APS_kinase; Adenylylsulphate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KUT8 Q7KUT8
    Q8IQV1 Q8IQV1
    Q961A8 Q961A8
    Q9VW48 Q9VW48

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