Tfpi2 tissue factor pathway inhibitor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfpi2provided by MGI
Official Full Name: tissue factor pathway inhibitor 2provided by MGI
Primary source: MGI:MGI:108543
See related: Ensembl:ENSMUSG00000029664 AllianceGenome:MGI:108543
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP5/TFPI-2
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within blood coagulation and negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; liver; lung; small intestine; and spleen. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 13.4), placenta adult (RPKM 12.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 1.81 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (3962589..3988977, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (3962589..3988978, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
Title: TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
TFPI-2 Protects Against Gram-Negative Bacterial Infection.
Title: TFPI-2 Protects Against Gram-Negative Bacterial Infection.
Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin, factor XIa, and kallikrein
Title: S2'-subsite variations between human and mouse enzymes (plasmin, factor XIa, kallikrein) elucidate inhibition differences by tissue factor pathway inhibitor -2 domain1-wild-type, Leu17Arg-mutant and aprotinin.
A novel mouse model is presented and can be used to investigate the role of TFPI-2 in the process of atherosclerosis.
Title: Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
Over-expression of TFPI-2 promotes atherosclerotic plaque stability, which may be related to inhibition of matrix metalloproteinases.
Title: Over-expression of TFPI-2 promotes atherosclerotic plaque stability by inhibiting MMPs in apoE-/- mice.
Dynamic changes of Tfpi2 associated with Il-1beta and Tnf-alpha in the development of acute lung injury are reported.
Title: Dynamic changes of tissue factor pathway inhibitor type 2 associated with IL-1beta and TNF-alpha in the development of murine acute lung injury.
Deficiency for the histone methyltransferase EHMT2 or for the Polycomb group protein EED, leads to biallelic expression of Tfpi2 in the extra-embryonic lineages, whereas the other genes in the cluster maintain correct imprinting.
Title: Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.
Bovine TFPI2 was compared to mouse TFPI2.
Title: Molecular cloning, expression, and characterization of bovine tissue factor pathway inhibitor-2.
Our data suggest that TFPI-2 may be an important regulator of aberrant angiogenesis associated with tumor growth/metastasis, cardiovascular diseases, chronic inflammation, or diabetes.
Title: Adenovirus-mediated expression of tissue factor pathway inhibitor-2 inhibits endothelial cell migration and angiogenesis.
human and murine TFPI-2 have different functions in liver regulation during inflammation in the two species
Title: Expression of tissue factor pathway inhibitor-2 in murine and human liver regulation during inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tissue factor pathway inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001381907.1 → NP_001368836.1 tissue factor pathway inhibitor 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC022235

Conserved Domains (2) summary

cd00109
Location:30 → 83

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:151 → 203

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
NM_001381908.1 → NP_001368837.1 tissue factor pathway inhibitor 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC022235

Conserved Domains (2) summary

cd00109
Location:70 → 123

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:191 → 243

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
NM_009364.4 → NP_033390.1 tissue factor pathway inhibitor 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_033390.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.

Source sequence(s)

AK132268, BU755117

Consensus CDS

CCDS19892.1

UniProtKB/Swiss-Prot

O35536

UniProtKB/TrEMBL

Q3V1S9

Related

ENSMUSP00000031674.8, ENSMUST00000031674.11

Conserved Domains (2) summary

cd00109
Location:34 → 87

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:155 → 206

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RNA

NR_138566.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' terminal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq criteria.

Source sequence(s)

AC022235

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

3962589..3988977 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241056.3 → XP_011239358.1 tissue factor pathway inhibitor 2 isoform X2

Conserved Domains (1) summary

pfam00014
Location:90 → 141

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
XM_011241055.4 → XP_011239357.1 tissue factor pathway inhibitor 2 isoform X1

See identical proteins and their annotated locations for XP_011239357.1

UniProtKB/Swiss-Prot

O35536

UniProtKB/TrEMBL

Q3V1S9

Conserved Domains (2) summary

cd00109
Location:34 → 87

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:155 → 206

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain