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    Klrb1c killer cell lectin-like receptor subfamily B member 1C [ Mus musculus (house mouse) ]

    Gene ID: 17059, updated on 12-May-2024

    Summary

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    Official Symbol
    Klrb1cprovided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily B member 1Cprovided by MGI
    Primary source
    MGI:MGI:107538
    See related
    Ensembl:ENSMUSG00000030325 AllianceGenome:MGI:107538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nk1; Ly59; Nk-1; CD161; Ly-59; Ly55c; NK1.1; NKRP1; Nk1.2; Klrb1b; NK-RP1; Nk-1.2; Nkrp1b; Nkrp1c; ly-55c; NKRP140; NKR-P1.9
    Summary
    Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 16.6) and spleen adult (RPKM 2.1) See more
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    Genomic context

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    Location:
    6 F3; 6 63.09 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128755448..128765514, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128778485..128788641, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17454 Neighboring gene C-type lectin domain family 2, member h Neighboring gene STARR-seq mESC enhancer starr_17455 Neighboring gene killer cell lectin-like receptor subfamily B member 1 Neighboring gene STARR-seq mESC enhancer starr_17456 Neighboring gene STARR-seq mESC enhancer starr_17457 Neighboring gene STARR-seq mESC enhancer starr_17458 Neighboring gene STARR-positive B cell enhancer ABC_E238 Neighboring gene STARR-seq mESC enhancer starr_17462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:128749513-128749622 Neighboring gene STARR-positive B cell enhancer ABC_E284 Neighboring gene predicted gene, 34755 Neighboring gene killer cell lectin-like receptor subfamily B member 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice. Berriel E, et al. Cancer Immunol Immunother, 2021 Dec. PMID 33944981, Free PMC Article
    2. The C-type lectin-like receptor Nkrp1b: Structural proteomics reveals features affecting protein conformation and interactions. Hernychová L, et al. J Proteomics, 2019 Mar 30. PMID 30414947
    3. Re-evaluation of the involvement of NK cells and C-type lectin-like NK receptors in modulation of immune responses by multivalent GlcNAc-terminated oligosaccharides. Grobárová V, et al. Immunol Lett, 2013 Nov-Dec. PMID 24076118
    4. Molecular architecture of mouse activating NKR-P1 receptors. Kolenko P, et al. J Struct Biol, 2011 Sep. PMID 21600988
    5. DC therapy induces long-term NK reactivity to tumors via host DC. Shimizu K, et al. Eur J Immunol, 2009 Feb. PMID 19180466

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling.
      Title: Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling.
    2. Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice.
      Title: Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice.
    3. data showed that both Nkrp1b protein variants form monomers and homodimers irrespective of the presence of the stalk.
      Title: The C-type lectin-like receptor Nkrp1b: Structural proteomics reveals features affecting protein conformation and interactions.
    4. Data suggest that expression of killer cell lectin-like receptor subfamily B member 1C protein (NK1.1) defines a population of rapidly expanding effector CD4(+) T cells that specifically promote plasmablast induction during Plasmodium infection.
      Title: NK1.1 Expression Defines a Population of CD4(+) Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection.
    5. Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface.
      Title: Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
    6. The adoptive transfer of NK1.1(-) CD4(+) NKG2D(+) cells suppressed DSS-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.
      Title: NK1.1(-) CD4(+) NKG2D(+) T cells suppress DSS-induced colitis in mice through production of TGF-β.
    7. MCMV may encode a novel Clr-b-independent immunoevasin that functionally engages the NKR-P1B receptor.
      Title: Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.
    8. NK1.1+ CD8+ T cells have a role in TGF-beta control and contribute to early microbial pathogen response
      Title: NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response.
    9. Data indicate that C-type lectin-like NK receptor NKR-P1C proteins showed no affinity to the various neoglycoproteins.
      Title: Re-evaluation of the involvement of NK cells and C-type lectin-like NK receptors in modulation of immune responses by multivalent GlcNAc-terminated oligosaccharides.
    10. 5-HT3 and NK1 immunopositive macrophages and mucosal mast cells in lamina propria release 5-HT and substance P, which in turn activate their corresponding receptors on mucosal cells in autocrine and paracrine manners.
      Title: Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Not Applicable (2)  1 citation
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within natural killer cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily B member 1C
    Names
    CD161 antigen-like family member C
    NKR-P1 40
    NKR-P1B
    killer cell lectin-like receptor subfamily A member 1C
    lymphocyte antigen 55 complex, locus C
    lymphocyte antigen 55c
    lymphocyte antigen 59
    natural killer cell receptor protein NKR-P1C
    natural killer cell receptor-P1
    natural killer cell surface protein P1-40
    natural killer cell-associated antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159904.2 → NP_001153376.2  killer cell lectin-like receptor subfamily B member 1C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102693
      Consensus CDS
      CCDS51919.1
      UniProtKB/Swiss-Prot
      P27814, Q541U5, Q925G3
      UniProtKB/TrEMBL
      A0A1U9W192
      Related
      ENSMUSP00000134504.3, ENSMUST00000174404.8
      Conserved Domains (1) summary
      cd03593
      Location:94 → 212
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_008527.3 → NP_032553.3  killer cell lectin-like receptor subfamily B member 1C isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC102693
      Consensus CDS
      CCDS39654.2
      UniProtKB/TrEMBL
      A0A1U9W195
      Related
      ENSMUSP00000127297.4, ENSMUST00000167691.9
      Conserved Domains (1) summary
      cd03593
      Location:91 → 209
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128755448..128765514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27814.2 GenPept UniProtKB/Swiss-Prot:P27814

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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