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    Cmklr2 chemerin chemokine-like receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25457, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cmklr2provided by RGD
    Official Full Name
    chemerin chemokine-like receptor 2provided by RGD
    Primary source
    RGD:2728
    See related
    Ensembl:ENSRNOG00000045532 AllianceGenome:RGD:2728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr1
    Summary
    Predicted to enable G protein-coupled receptor activity; adipokinetic hormone receptor activity; and peptide binding activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human CMKLR2 (chemerin chemokine-like receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 5.5), Heart (RPKM 1.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cmklr2 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (72077164..72111979, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (64583310..64617883, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (69958607..69991410, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 51 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene zinc finger, DBF-type containing 2 Neighboring gene cytochrome c oxidase subunit 5B, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mapping studies of two G protein-coupled receptor genes: an amino acid difference may confer a functional variation between a human and rodent receptor. Marchese A, et al. Biochem Biophys Res Commun, 1994 Dec 30. PMID 7811287
    2. Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature. Kennedy AJ, et al. J Am Heart Assoc, 2016 Oct 14. PMID 27742615, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CMKLR1 and GPR1 were widely expressed in vascular smooth muscle.
      Title: Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adipokinetic hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adipokinetic hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables adipokinetic hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adipokinetic hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    chemerin-like receptor 2
    Names
    G protein-coupled receptor 1
    G-protein copled receptor 1
    chemokine-like receptor 2
    probable G-protein coupled receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012961.2 → NP_037093.2  chemerin-like receptor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      M0RCK7, P46090
      Related
      ENSRNOP00000067327.1, ENSRNOT00000072737.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      72077164..72111979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266682.1 → XP_063122752.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      M0RCK7, P46090

    2. XM_039083036.1 → XP_038938964.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      M0RCK7, P46090
      Conserved Domains (1) summary
      cd15119
      Location:39 → 313
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46090.2 GenPept UniProtKB/Swiss-Prot:P46090

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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