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    Cd200r3 CD200 receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 74603, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Cd200r3provided by MGI
    Official Full Name
    CD200 receptor 3provided by MGI
    Primary source
    MGI:MGI:1921853
    See related
    Ensembl:ENSMUSG00000036172 AllianceGenome:MGI:1921853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mCD200RLb; 4733401I18Rik; 4833409J19Rik
    Summary
    Enables signaling receptor activity. Predicted to be involved in regulation of neuroinflammatory response. Located in external side of plasma membrane. Orthologous to human CD200R1 (CD200 receptor 1) and CD200R1L (CD200 receptor 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 2.4) and liver E14.5 (RPKM 0.1) See more
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    Genomic context

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    Location:
    16 B4- B5; 16 29.25 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44763959..44878728)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44943596..45058365)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene Cd200 receptor 2 Neighboring gene predicted gene, 53957 Neighboring gene Cd200 receptor 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7453 Neighboring gene STARR-seq mESC enhancer starr_40912 Neighboring gene predicted gene, 53958 Neighboring gene coiled-coil domain containing 80

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance. Rosenblum MD, et al. Blood, 2004 Apr 1. PMID 14644999
    2. Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. Kojima T, et al. J Immunol, 2007 Nov 15. PMID 17982101
    3. Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor. Hatherley D, et al. J Immunol, 2005 Aug 15. PMID 16081818
    4. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. Voehringer D, et al. J Biol Chem, 2004 Dec 24. PMID 15471863
    5. CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. Gorczynski R, et al. J Immunol, 2004 Jun 15. PMID 15187158

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD200R3 functions as an activating receptor on mast cells and basophils to regulate IgE-independent immune responses in cooperation with an inhibitory receptor CD200R
      Title: Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner.
    2. Expression of the immunoregulatory protein CD200 increases as murine dendritic cells undergo apoptosis.
      Title: CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance.
    3. during parasitic helminth infection, we identified CD200 receptor-like 3 as a transcript highly expressed in basophils and mast cells
      Title: CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123954

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of neuroinflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell surface glycoprotein CD200 receptor 3
    Names
    CD200 cell surface glycoprotein receptor 3
    CD200 cell surface glycoprotein receptor-like 3
    CD200 cell surface glycoprotein receptor-like b
    CD200 receptor-like 3
    CD200RLb
    cell surface glycoprotein OX2 receptor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128132.1 → NP_001121604.1  cell surface glycoprotein CD200 receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001121604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC124600
      Consensus CDS
      CCDS49856.1
      UniProtKB/TrEMBL
      E9Q7T2
      Related
      ENSMUSP00000110258.4, ENSMUST00000114611.10

    2. NM_001128133.1 → NP_001121605.1  cell surface glycoprotein CD200 receptor 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001121605.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC124600, AK014671
      Consensus CDS
      CCDS49858.1
      UniProtKB/Swiss-Prot
      Q5UKY4
      Related
      ENSMUSP00000110269.4, ENSMUST00000114622.10

    3. NM_027578.1 → NP_081854.1  cell surface glycoprotein CD200 receptor 3 isoform 4 precursor

      See identical proteins and their annotated locations for NP_081854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC124600
      Consensus CDS
      CCDS49859.1
      UniProtKB/Swiss-Prot
      Q5UKY4
      Related
      ENSMUSP00000132938.2, ENSMUST00000171779.8

    4. NM_029018.4 → NP_083294.2  cell surface glycoprotein CD200 receptor 3 isoform 3 precursor

      See identical proteins and their annotated locations for NP_083294.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC124600, AK040868, AY230199
      Consensus CDS
      CCDS49857.1
      UniProtKB/TrEMBL
      E9Q7T2
      Related
      ENSMUSP00000130480.2, ENSMUST00000164007.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44763959..44878728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246035.1 → XP_011244337.1  cell surface glycoprotein CD200 receptor 3 isoform X7

    2. XM_011246032.2 → XP_011244334.1  cell surface glycoprotein CD200 receptor 3 isoform X3

    3. XM_011246030.3 → XP_011244332.1  cell surface glycoprotein CD200 receptor 3 isoform X1

    4. XM_011246031.4 → XP_011244333.1  cell surface glycoprotein CD200 receptor 3 isoform X2

    5. XM_017317153.2 → XP_017172642.1  cell surface glycoprotein CD200 receptor 3 isoform X4

      UniProtKB/TrEMBL
      E9Q7T2

    6. XM_017317152.2 → XP_017172641.1  cell surface glycoprotein CD200 receptor 3 isoform X4

      UniProtKB/TrEMBL
      E9Q7T2

    7. XM_006522674.4 → XP_006522737.1  cell surface glycoprotein CD200 receptor 3 isoform X4

      See identical proteins and their annotated locations for XP_006522737.1

      UniProtKB/TrEMBL
      E9Q7T2
      Related
      ENSMUSP00000110260.3, ENSMUST00000114613.9

    8. XM_017317154.2 → XP_017172643.1  cell surface glycoprotein CD200 receptor 3 isoform X6

      UniProtKB/Swiss-Prot
      Q5UKY4
      Related
      ENSMUSP00000110259.2, ENSMUST00000114612.8

    9. XM_011246033.2 → XP_011244335.1  cell surface glycoprotein CD200 receptor 3 isoform X5

      UniProtKB/TrEMBL
      E9Q7T2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5UKY4.1 GenPept UniProtKB/Swiss-Prot:Q5UKY4

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