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    Pak4 p21 (RAC1) activated kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 70584, updated on 12-May-2024

    Summary

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    Official Symbol
    Pak4provided by MGI
    Official Full Name
    p21 (RAC1) activated kinase 4provided by MGI
    Primary source
    MGI:MGI:1917834
    See related
    Ensembl:ENSMUSG00000030602 AllianceGenome:MGI:1917834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1142; 5730488L07Rik
    Summary
    Enables protein kinase activity. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 40.7), duodenum adult (RPKM 33.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pak4 in Genome Data Viewer
    Location:
    7 A3- B1; 7 16.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28258244..28297609, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28558819..28598184, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342572-29342755 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342797-29343021 Neighboring gene predicted gene, 38977 Neighboring gene microRNA 7049 Neighboring gene STARR-seq mESC enhancer starr_18428 Neighboring gene acid phosphatase 7, tartrate resistant Neighboring gene STARR-seq mESC enhancer starr_18429 Neighboring gene STARR-seq mESC enhancer starr_18430 Neighboring gene STARR-seq mESC enhancer starr_18432 Neighboring gene STARR-seq mESC enhancer starr_18434 Neighboring gene F-box protein 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Ma W, et al. Nat Cancer, 2021 Jan. PMID 35121889, Free PMC Article
    2. p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: Role of nuclear factor erythroid 2-related factor 2 phosphorylation. Mao Y, et al. Hepatology, 2022 Aug. PMID 35108418
    3. PAK4 inhibition improves PD-1 blockade immunotherapy. Abril-Rodriguez G, et al. Nat Cancer, 2020. PMID 34368780, Free PMC Article
    4. Stimulation of melanin synthesis by UVB is mediated by NO/cGMP/PKG cascade targeting PAK4 in vitro. Xue L, et al. In Vitro Cell Dev Biol Anim, 2021 Mar. PMID 33638135
    5. PAK4 suppresses motor neuron degeneration in hSOD1(G93A) -linked amyotrophic lateral sclerosis cell and rat models. Cong C, et al. Cell Prolif, 2021 Apr. PMID 33615605, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
      Title: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
    2. p21-activated kinase 4 suppresses fatty acid beta-oxidation and ketogenesis by phosphorylating NCoR1.
      Title: p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1.
    3. P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation.
      Title: P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation.
    4. p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: Role of nuclear factor erythroid 2-related factor 2 phosphorylation.
      Title: p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: Role of nuclear factor erythroid 2-related factor 2 phosphorylation.
    5. p21-activated kinase 4 controls the aggregation of alpha-synuclein by reducing the monomeric and aggregated forms of alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
      Title: p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
    6. PAK4 inhibition improves PD-1 blockade immunotherapy.
      Title: PAK4 inhibition improves PD-1 blockade immunotherapy.
    7. Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma.
      Title: Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma.
    8. p21-activated kinase 4 phosphorylates peroxisome proliferator-activated receptor Upsilon and suppresses skeletal muscle regeneration.
      Title: p21-activated kinase 4 phosphorylates peroxisome proliferator-activated receptor Υ and suppresses skeletal muscle regeneration.
    9. Stimulation of melanin synthesis by UVB is mediated by NO/cGMP/PKG cascade targeting PAK4 in vitro.
      Title: Stimulation of melanin synthesis by UVB is mediated by NO/cGMP/PKG cascade targeting PAK4 in vitro.
    10. PAK4 suppresses motor neuron degeneration in hSOD1(G93A) -linked amyotrophic lateral sclerosis cell and rat models.
      Title: PAK4 suppresses motor neuron degeneration in hSOD1(G93A) -linked amyotrophic lateral sclerosis cell and rat models.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 4
    Names
    PAK-4
    p21 protein (Cdc42/Rac)-activated kinase 4
    p21-activated kinase 4
    NP_081746.1
    XP_017167785.1
    XP_017167786.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027470.3 → NP_081746.1  serine/threonine-protein kinase PAK 4

      See identical proteins and their annotated locations for NP_081746.1

      Status: VALIDATED

      Source sequence(s)
      AC136456, AK017713, BB839524, BQ572351, BY197606, CF172418
      Consensus CDS
      CCDS21049.1
      UniProtKB/Swiss-Prot
      Q6ZPX0, Q80Z97, Q8BTW9, Q9CS71
      Related
      ENSMUSP00000103918.2, ENSMUST00000108283.8
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28258244..28297609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312296.1 → XP_017167785.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZPX0, Q80Z97, Q8BTW9, Q9CS71
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017312297.1 → XP_017167786.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZPX0, Q80Z97, Q8BTW9, Q9CS71
      Related
      ENSMUSP00000032823.5, ENSMUST00000032823.5
      Conserved Domains (2) summary
      cd01093
      Location:10 → 48
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:302 → 593
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTW9.1 GenPept UniProtKB/Swiss-Prot:Q8BTW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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