Stard3nl STARD3 N-terminal like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stard3nlprovided by MGI
Official Full Name: STARD3 N-terminal likeprovided by MGI
Primary source: MGI:MGI:1923455
See related: Ensembl:ENSMUSG00000003062 AllianceGenome:MGI:1923455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MENTHO; 0610035N01Rik; 6530409L22Rik
Summary: Predicted to enable cholesterol binding activity and protein homodimerization activity. Predicted to be involved in vesicle tethering to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Is expressed in respiratory system cartilage; sensory organ; skeleton; and tarsus. Orthologous to human STARD3NL (STARD3 N-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 24.1), whole brain E14.5 (RPKM 18.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A2; 13 6.89 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (19541846..19579983, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (19357676..19395813, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/beta-catenin pathway via binding to Annexin A2 in osteoporosis.
Title: STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW124774 (e-PCR)
- UniSTS:185967

RH129383 (e-PCR)
- UniSTS:212690

D13Mit153 (e-PCR), detects polymorphism
- UniSTS:126975

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle tethering to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle tethering to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum-endosome membrane contact site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-endosome membrane contact site	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane contact site	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: STARD3 N-terminal-like protein

Names: MLN64 N-terminal domain homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347485.1 → NP_001334414.1 STARD3 N-terminal-like protein isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.

Source sequence(s)

AK018331, BG071347, CJ135250, DV648392

Consensus CDS

CCDS84008.1

UniProtKB/TrEMBL

A0A0G2JE93, Q3U852

Related

ENSMUSP00000142680.2, ENSMUST00000200323.3
NM_024270.3 → NP_077232.2 STARD3 N-terminal-like protein isoform a

See identical proteins and their annotated locations for NP_077232.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).

Source sequence(s)

BG084215, BP772163, CO039188, DV648392

Consensus CDS

CCDS26259.1

UniProtKB/Swiss-Prot

Q3U8Q7, Q99J63, Q9D356, Q9DCI3

UniProtKB/TrEMBL

Q3U852

Related

ENSMUSP00000037991.8, ENSMUST00000039694.13

Conserved Domains (1) summary

pfam10457
Location:49 → 212

MENTAL; Cholesterol-capturing domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

19541846..19579983 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158216.1 → XP_036014109.1 STARD3 N-terminal-like protein isoform X2

UniProtKB/TrEMBL

Q3U852

Conserved Domains (1) summary

pfam10457
Location:104 → 267

MENTAL; Cholesterol-capturing domain
XM_036158217.1 → XP_036014110.1 STARD3 N-terminal-like protein isoform X3

UniProtKB/Swiss-Prot

Q3U8Q7, Q99J63, Q9D356, Q9DCI3

UniProtKB/TrEMBL

Q3U852

Conserved Domains (1) summary

pfam10457
Location:49 → 212

MENTAL; Cholesterol-capturing domain
XM_030247456.1 → XP_030103316.1 STARD3 N-terminal-like protein isoform X3

UniProtKB/Swiss-Prot

Q3U8Q7, Q99J63, Q9D356, Q9DCI3

UniProtKB/TrEMBL

Q3U852

Conserved Domains (1) summary

pfam10457
Location:49 → 212

MENTAL; Cholesterol-capturing domain
XM_030247454.2 → XP_030103314.1 STARD3 N-terminal-like protein isoform X1

Conserved Domains (1) summary

pfam10457
Location:104 → 268

MENTAL; Cholesterol-capturing domain